Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

Overview

Journal Science

Specialty Science

Date 2010 Mar 27

PMID 20339031

Citations 368

Authors

Rui Xu

Damian C Ekiert

Jens C Krause

Rong Hai

James E Crowe Jr

Ian A Wilson

Affiliations

Soon will be listed here.

Abstract

The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.

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