Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2016 Dec 8

PMID 27923954

Citations 40

Authors

Joshua G Petrie

Kaela Parkhouse

Suzanne E Ohmit

Ryan E Malosh

Arnold S Monto

Scott E Hensley

Affiliations

Soon will be listed here.

Abstract

During the 2013-2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013-2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1)pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain.

Citing Articles

A neuraminidase-based inactivated influenza virus vaccine significantly reduced virus replication and pathology following homologous challenge in swine.

Kaplan B, Souza C, Kimble J, Brand M, Anderson T, Gauger P Vaccine. 2024; 46:126574.

PMID: 39645432 PMC: 11874874. DOI: 10.1016/j.vaccine.2024.126574.

High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains.

Loes A, Tarabi R, Huddleston J, Touyon L, Wong S, Cheng S J Virol. 2024; 98(10):e0068924.

PMID: 39315814 PMC: 11494878. DOI: 10.1128/jvi.00689-24.

Respiratory Viral Infections from 2015 to 2022 in the HIVE Cohort of American Households: Incidence, illness characteristics, and seasonality.

Monto A, Foster-Tucker J, Callear A, Leis A, Godonou E, Smith M J Infect Dis. 2024; .

PMID: 39179953 PMC: 11847950. DOI: 10.1093/infdis/jiae423.

Immune imprinting in early life shapes cross-reactivity to influenza B virus haemagglutinin.

Edler P, Schwab L, Aban M, Wille M, Spirason N, Deng Y Nat Microbiol. 2024; 9(8):2073-2083.

PMID: 38890491 DOI: 10.1038/s41564-024-01732-8.

High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains.

Loes A, Tarabi R, Huddleston J, Touyon L, Wong S, Cheng S bioRxiv. 2024; .

PMID: 38496577 PMC: 10942427. DOI: 10.1101/2024.03.08.584176.

References

Beyer W, Palache A, Sprenger M, Hendriksen E, Tukker J, Darioli R . Effects of repeated annual influenza vaccination on vaccine sero-response in young and elderly adults. Vaccine. 1996; 14(14):1331-9. DOI: 10.1016/s0264-410x(96)00058-8. View

Epperson S, Blanton L, Kniss K, Mustaquim D, Steffens C, Wallis T . Influenza activity - United States, 2013-14 season and composition of the 2014-15 influenza vaccines. MMWR Morb Mortal Wkly Rep. 2014; 63(22):483-90. PMC: 5779357. View

Treanor J, Talbot H, Ohmit S, Coleman L, Thompson M, Cheng P . Effectiveness of seasonal influenza vaccines in the United States during a season with circulation of all three vaccine strains. Clin Infect Dis. 2012; 55(7):951-9. PMC: 3657521. DOI: 10.1093/cid/cis574. View

. Update: influenza activity - United States, 2009-10 season. MMWR Morb Mortal Wkly Rep. 2010; 59(29):901-8. View

Ohmit S, Petrie J, Malosh R, Johnson E, Truscon R, Aaron B . Substantial Influenza Vaccine Effectiveness in Households With Children During the 2013-2014 Influenza Season, When 2009 Pandemic Influenza A(H1N1) Virus Predominated. J Infect Dis. 2015; 213(8):1229-36. PMC: 4799665. DOI: 10.1093/infdis/jiv563. View

Ohmit S, Thompson M, Petrie J, Thaker S, Jackson M, Belongia E . Influenza vaccine effectiveness in the 2011-2012 season: protection against each circulating virus and the effect of prior vaccination on estimates. Clin Infect Dis. 2013; 58(3):319-27. PMC: 4007111. DOI: 10.1093/cid/cit736. View

Gaglani M, Pruszynski J, Murthy K, Clipper L, Robertson A, Reis M . Influenza Vaccine Effectiveness Against 2009 Pandemic Influenza A(H1N1) Virus Differed by Vaccine Type During 2013-2014 in the United States. J Infect Dis. 2016; 213(10):1546-56. PMC: 4837903. DOI: 10.1093/infdis/jiv577. View

Hancock K, Veguilla V, Lu X, Zhong W, Butler E, Sun H . Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med. 2009; 361(20):1945-52. DOI: 10.1056/NEJMoa0906453. View

Monto A, Petrie J, Cross R, Johnson E, Liu M, Zhong W . Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection. J Infect Dis. 2015; 212(8):1191-9. DOI: 10.1093/infdis/jiv195. View

10.

Hobson D, CURRY R, Beare A . The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses. J Hyg (Lond). 1972; 70(4):767-77. PMC: 2130285. DOI: 10.1017/s0022172400022610. View

11.

Linderman S, Chambers B, Zost S, Parkhouse K, Li Y, Herrmann C . Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season. Proc Natl Acad Sci U S A. 2014; 111(44):15798-803. PMC: 4226110. DOI: 10.1073/pnas.1409171111. View

12.

Neher R, Bedford T . nextflu: real-time tracking of seasonal influenza virus evolution in humans. Bioinformatics. 2015; 31(21):3546-8. PMC: 4612219. DOI: 10.1093/bioinformatics/btv381. View

13.

. Swine influenza A (H1N1) infection in two children--Southern California, March-April 2009. MMWR Morb Mortal Wkly Rep. 2009; 58(15):400-2. View