Aging-associated Reduction of Chromosomal Histones in Mammalian Oocytes

Overview

Journal Genes Cells

Specialties Cell Biology
Molecular Biology

Date 2024 Jul 24

PMID 39044347

Authors

Masashi Mori

Manami Koshiguchi

Osamu Takenouchi

Mei A Mukose

Hinako M Takase

Tappei Mishina

Hailiang Mei

Miho Kihara

Takaya Abe

Azusa Inoue

Tomoya S Kitajima

Affiliations

Soon will be listed here.

Abstract

Mammalian oocytes undergo a long-term meiotic arrest that can last for almost the entire reproductive lifespan. This arrest occurs after DNA replication and is prolonged with age, which poses a challenge to oocytes in maintaining replication-dependent chromosomal proteins required for the completion of meiosis. In this study, we show that chromosomal histones are reduced with age in mouse oocytes. Both types of histone H3 variants, replication-dependent H3.1/H3.2 and replication-independent H3.3, decrease with age. Aging-associated histone reduction is associated with transcriptomic features that are caused by genetic depletion of histone H3.3. Neither the genetic reduction of chromosomal H3.1/H3.2 nor H3.3 accelerates the aging-associated increase in premature chromosome separation that causes meiotic segregation errors. We suggest that aging-associated reduction of chromosomal histones is linked to several transcriptomic abnormalities but does not significantly contribute to errors in meiotic chromosome segregation during the reproductive lifespan of mice.

Citing Articles

Aging-associated reduction of chromosomal histones in mammalian oocytes.

Mori M, Koshiguchi M, Takenouchi O, Mukose M, Takase H, Mishina T Genes Cells. 2024; 29(10):808-819.

PMID: 39044347 PMC: 11555632. DOI: 10.1111/gtc.13146.

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