Tomoya S Kitajima
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Explore the profile of Tomoya S Kitajima including associated specialties, affiliations and a list of published articles.
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46
Citations
2162
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Recent Articles
1.
Takase H, Mishina T, Hayashi T, Yoshimura M, Kuse M, Nikaido I, et al.
PLoS One
. 2024 Oct;
19(10):e0311978.
PMID: 39441825
Primordial follicle activation (PFA) is a pivotal event in female reproductive biology, coordinating the transition from quiescent to growing follicles. This study employed comprehensive single-cell RNA sequencing to gain insights...
2.
Kouznetsova A, Valentiniene S, Liu J, Kitajima T, Brismar H, Hoog C
Front Cell Dev Biol
. 2024 Oct;
12:1470981.
PMID: 39355122
Correct chromosome segregation is essential to preserve genetic integrity. The two protein kinases, Aurora B and its meiotic homolog Aurora C, regulate attachments between chromosomal kinetochores and microtubules, thereby contributing...
3.
Asai K, Zhou Y, Takenouchi O, Kitajima T
Science
. 2024 Sep;
385(6715):1366-1375.
PMID: 39298589
Faithful chromosome segregation requires biorientation, where the pair of kinetochores on the chromosome establish bipolar microtubule attachment. The integrity of the kinetochore, a macromolecular complex built on centromeric DNA, is...
4.
Takahashi S, Kyogoku H, Hayakawa T, Miura H, Oji A, Kondo Y, et al.
Nature
. 2024 Aug;
633(8030):686-694.
PMID: 39198647
Faithful DNA replication is essential for genome integrity. Under-replicated DNA leads to defects in chromosome segregation, which are common during embryogenesis. However, the regulation of DNA replication remains poorly understood...
5.
Mori M, Koshiguchi M, Takenouchi O, Mukose M, Takase H, Mishina T, et al.
Genes Cells
. 2024 Jul;
29(10):808-819.
PMID: 39044347
Mammalian oocytes undergo a long-term meiotic arrest that can last for almost the entire reproductive lifespan. This arrest occurs after DNA replication and is prolonged with age, which poses a...
6.
Takenouchi O, Sakakibara Y, Kitajima T
Science
. 2024 Jul;
385(6706):eadn5529.
PMID: 39024439
Meiotic errors of relatively small chromosomes in oocytes result in egg aneuploidies that cause miscarriages and congenital diseases. Unlike somatic cells, which preferentially mis-segregate larger chromosomes, aged oocytes preferentially mis-segregate...
7.
Aizawa E, Ozonov E, Kawamura Y, Dumeau C, Nagaoka S, Kitajima T, et al.
EMBO J
. 2023 Oct;
42(23):e113955.
PMID: 37850882
Recent studies have reported the differentiation of pluripotent cells into oocytes in vitro. However, the developmental competence of in vitro-generated oocytes remains low. Here, we perform a comprehensive comparison of...
8.
Murakami K, Hamazaki N, Hamada N, Nagamatsu G, Okamoto I, Ohta H, et al.
Nature
. 2023 Mar;
615(7954):900-906.
PMID: 36922585
Sex chromosome disorders severely compromise gametogenesis in both males and females. In oogenesis, the presence of an additional Y chromosome or the loss of an X chromosome disturbs the robust...
9.
Kyogoku H, Kitajima T
J Reprod Dev
. 2022 Nov;
69(1):1-9.
PMID: 36436912
The study of the size of cells and organelles has a long history, dating back to the 1600s when cells were defined. In particular, various methods have elucidated the size...
10.
Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes
Ogonuki N, Kyogoku H, Hino T, Osawa Y, Fujiwara Y, Inoue K, et al.
EMBO Rep
. 2022 May;
23(7):e54992.
PMID: 35587095
Microinjection of spermatozoa or spermatids into oocytes is a major choice for infertility treatment. However, the use of premeiotic spermatocytes has never been considered because of its technical problems. Here,...