On the Ever-growing Functional Versatility of the CRISPR-Cas13 System

Overview

Journal Microb Biotechnol

Specialties Biotechnology
Microbiology

Date 2024 Feb 21

PMID 38381083

Authors

Roser Montagud-Martinez

Rosa Marquez-Costa

Maria Heras-Hernandez

Roswitha Dolcemascolo

Guillermo Rodrigo

Affiliations

Soon will be listed here.

Abstract

CRISPR-Cas systems evolved in prokaryotes to implement a powerful antiviral immune response as a result of sequence-specific targeting by ribonucleoproteins. One of such systems consists of an RNA-guided RNA endonuclease, known as CRISPR-Cas13. In very recent years, this system is being repurposed in different ways in order to decipher and engineer gene expression programmes. Here, we discuss the functional versatility of the CRISPR-Cas13 system, which includes the ability for RNA silencing, RNA editing, RNA tracking, nucleic acid detection and translation regulation. This functional palette makes the CRISPR-Cas13 system a relevant tool in the broad field of systems and synthetic biology.

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On the ever-growing functional versatility of the CRISPR-Cas13 system.

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