Integrins in Cell Migration--the Actin Connection

Overview

Journal J Cell Sci

Specialty Cell Biology

Date 2009 Jan 2

PMID 19118212

Citations 225

Authors

Miguel Vicente-Manzanares

Colin Kiwon Choi

Alan Rick Horwitz

Affiliations

Soon will be listed here.

Abstract

The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell, and the dynamic cross-linking of actin filaments promotes adhesion maturation. Breaking the linkage between actin and integrins leads to adhesion disassembly. Recent quantitative studies have revealed points of slippage in the linkage between actin and integrins, showing that it is not always efficient. Regulation of the assembly and organization of adhesions and their linkage to actin relies on signaling pathways that converge on components that control actin polymerization and organization.

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