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Guillaume Labrousse

Explore the profile of Guillaume Labrousse including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Quemerais C, Jean C, Brunel A, Decaup E, Labrousse G, Audureau H, et al.
Cancer Lett . 2025 Feb; 614:217538. PMID: 39924075
In pancreatic ductal adenocarcinoma (PDAC), fibroblast activation leads to excessive secretion of extracellular matrix (ECM) and soluble factors that regulate tumor progression, prompting investigation into endoplasmic reticulum (ER)-resident proteins that...
2.
Brunet M, Vargas C, Fanjul M, Varry D, Hanoun N, Larrieu D, et al.
J Pathol . 2024 Jun; 263(4-5):466-481. PMID: 38924548
The E3 ubiquitin ligase thyroid hormone receptor interacting protein 12 (TRIP12) has been implicated in pancreatic adenocarcinoma (PDAC) through its role in mediating the degradation of pancreas transcription factor 1a...
3.
Vienne M, Lopez C, Lulka H, Nevot A, Labrousse G, Dusetti N, et al.
Mol Ther Oncol . 2024 Apr; 32(1):200780. PMID: 38596307
Pancreatic cancer will soon become the second cause of death by cancer in Western countries. The main barrier to increase the survival of patients with this disease requires the development...
4.
Lumeau A, Bery N, Frances A, Gayral M, Labrousse G, Ribeyre C, et al.
Cancer Res . 2024 Jan; 84(7):1013-1028. PMID: 38294491
Significance: Cytidine deaminase reduces replication stress and regulates DNA replication to confer resistance to DNA-damaging drugs in pancreatic cancer, unveiling a molecular vulnerability that could enhance treatment response.
5.
Labrousse G, Vande Perre P, Parra G, Jaffrelot M, Leroy L, Chibon F, et al.
NAR Cancer . 2023 Mar; 5(2):zcad011. PMID: 36915289
The exonuclease domain of DNA polymerases epsilon's catalytic subunit (POLE) removes misincorporated nucleotides, called proofreading. POLE-exonuclease mutations cause colorectal- and endometrial cancers with an extreme burden of single nucleotide substitutions....
6.
Marcheteau E, Farge T, Peres M, Labrousse G, Tenet J, Delmas S, et al.
Cancers (Basel) . 2021 Aug; 13(16). PMID: 34439212
Triple-negative breast cancer (TNBC) is notoriously aggressive with a high metastatic potential, and targeted therapies are lacking. Using transcriptomic and histologic analysis of TNBC samples, we found that a high...