Clinical PDT Dose Dosimetry for Pleural Photofrin-mediated Photodynamic Therapy

Overview

Journal J Biomed Opt

Specialties Biomedical Engineering
Ophthalmology

Date 2024 Jan 15

PMID 38223299

Authors

Hongjing Sun

Yihong Ong

Weibing Yang

Dennis Sourvanos

Andreea Dimofte

Theresa M Busch

Sunil Singhal

Keith A Cengel

Timothy C Zhu

Affiliations

Soon will be listed here.

Abstract

Significance: Photodynamic therapy (PDT) is an established cancer treatment utilizing light-activated photosensitizers (PS). Effective treatment hinges on the PDT dose-dependent on PS concentration and light fluence-delivered over time. We introduce an innovative eight-channel PDT dose dosimetry system capable of concurrently measuring light fluence and PS concentration during treatment.

Aim: We aim to develop and evaluate an eight-channel PDT dose dosimetry system for simultaneous measurement of light fluence and PS concentration. By addressing uncertainties due to tissue variations, the system enhances accurate PDT dosimetry for improved treatment outcomes.

Approach: The study positions eight isotropic detectors strategically within the pleural cavity before PDT. These detectors are linked to bifurcated fibers, distributing signals to both a photodiode and a spectrometer. Calibration techniques are applied to counter tissue-related variations and improve measurement accuracy. The fluorescence signal is normalized using the measured light fluence, compensating for variations in tissue properties. Measurements were taken in 78 sites in the pleural cavities of 20 patients.

Results: Observations reveal minimal Photofrin concentration variation during PDT at each site, juxtaposed with significant intra- and inter-patient heterogeneities. Across 78 treated sites in 20 patients, the average Photofrin concentration for all 78 sites is , with a median concentration of . The average PDT dose for all 78 sites is , with a median dose of . A significant variation in PDT doses is observed, with a maximum difference of 3.1 times among all sites within one patient and a maximum difference of 9.8 times across all patients.

Conclusions: The introduced eight-channel PDT dose dosimetry system serves as a valuable real-time monitoring tool for light fluence and PS concentration during PDT. Its ability to mitigate uncertainties arising from tissue properties enhances dosimetry accuracy, thus optimizing treatment outcomes and bolstering the effectiveness of PDT in cancer therapy.

Citing Articles

A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy.

Sun H, Ong Y, Kim M, Dimofte A, Singhal S, Cengel K Antioxidants (Basel). 2025; 13(12).

PMID: 39765767 PMC: 11672818. DOI: 10.3390/antiox13121436.

In vivo, online label-free monitoring of heterogenous oxygen utilization during phototherapy with real-time ultrasound-guided photoacoustic imaging.

Langley A, Sweeney A, Shethia R, Bednarke B, Wulandana F, Xavierselvan M bioRxiv. 2024; .

PMID: 39677615 PMC: 11642742. DOI: 10.1101/2024.11.27.625759.

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