Timothy C Zhu
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Explore the profile of Timothy C Zhu including associated specialties, affiliations and a list of published articles.
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188
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2022
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Recent Articles
1.
Vikas V, Yang W, Wilson B, Zhu T, Hadfield R
Antioxidants (Basel)
. 2025 Feb;
14(2).
PMID: 40002363
The effectiveness of photodynamic therapy (PDT) for cancer treatment relies on the generation of cytotoxic singlet oxygen (O) in type II PDT. Hence, monitoring of O generation during PDT enables...
2.
Sun H, Kim M, Ong Y, Dimofte A, Singhal S, Busch T, et al.
Photochem Photobiol
. 2025 Jan;
PMID: 39838651
Photodynamic therapy (PDT) has shown promise as an adjuvant treatment for malignant pleural mesothelioma when combined with surgical resection. Accurate light dosimetry is critical for treatment efficacy. This study presents...
3.
Zhu T, Pogue B, Dimofte A, Finlay J, Lilge L, Sunar U, et al.
Med Phys
. 2025 Jan;
52(3):1354-1371.
PMID: 39815459
Photodynamic therapy (PDT) is a treatment modality clinically approved for several oncologic indications, including esophageal and endobronchial cancers, precancerous conditions including Barrett's esophagus and actinic keratosis, and benign conditions like...
4.
Yang W, Johnson M, Lu B, Sourvanos D, Sun H, Dimofte A, et al.
Antioxidants (Basel)
. 2025 Jan;
13(12).
PMID: 39765787
The direct detection of singlet-state oxygen (O) constitutes the holy grail dosimetric method for type-II photodynamic therapy (PDT), a goal that can be quantified using multispectral singlet oxygen near-infrared luminescence...
5.
A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy
Sun H, Ong Y, Kim M, Dimofte A, Singhal S, Cengel K, et al.
Antioxidants (Basel)
. 2025 Jan;
13(12).
PMID: 39765767
Photodynamic therapy (PDT) relies on the interactions between light, photosensitizers, and tissue oxygen to produce cytotoxic reactive oxygen species (ROS), primarily singlet oxygen (O) through Type II photochemical reactions, along...
6.
Cui S, Guo X, Wang S, Wei Z, Huang D, Zhang X, et al.
Pharmaceuticals (Basel)
. 2024 Oct;
17(10).
PMID: 39458915
Photodynamic therapy (PDT) is a therapeutic modality that depends on the interaction of light, photosensitizers, and oxygen. The photon absorption and energy transfer process can lead to the Type II...
7.
Yang W, Rastogi V, Sun H, Sharma D, Wilson B, Hadfield R, et al.
Proc SPIE Int Soc Opt Eng
. 2024 Feb;
12359.
PMID: 38419618
Direct detection of singlet-state oxygen ([O]) constitutes the holy grail dosimetric method for type II PDT, a goal that can be quantified using multispectral singlet oxygen dosimetry (MSOLD). However, the...
8.
Sourvanos D, Zhu T, Dimofte A, Busch T, Lander B, Burrell J, et al.
Photodiagnosis Photodyn Ther
. 2024 Feb;
46:104015.
PMID: 38373469
Objective: Photodynamic Therapy (PDT) and Photobiomodulation (PBM) are recognized for their potential in treating head and neck conditions. The heterogeneity of human tissue optical properties presents a challenge for effective...
9.
Sourvanos D, Sun H, Zhu T, Dimofte A, Byrd B, Busch T, et al.
Photodiagnosis Photodyn Ther
. 2024 Feb;
46:104014.
PMID: 38346466
Objective: The primary aim was to investigate emerging 3D printing and optical acquisition technologies to refine and enhance photodynamic therapy (PDT) dosimetry in the management of malignant pleural mesothelioma (MPM)....
10.
Sun H, Ong Y, Yang W, Sourvanos D, Dimofte A, Busch T, et al.
J Biomed Opt
. 2024 Jan;
29(1):018001.
PMID: 38223299
Significance: Photodynamic therapy (PDT) is an established cancer treatment utilizing light-activated photosensitizers (PS). Effective treatment hinges on the PDT dose-dependent on PS concentration and light fluence-delivered over time. We introduce...