CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility

Overview

Journal Cancer Res

Specialty Oncology

Date 2023 Dec 20

PMID 38117513

Authors

Mulong Du

Junyi Xin

Rui Zheng

Qianyu Yuan

Zhihui Wang

Hongliang Liu

Hanting Liu

Guoshuai Cai

Demetrius Albanes

Stephen Lam

Adonina Tardon

Chu Chen

Stig E Bojesen

Maria Teresa Landi

Mattias Johansson

Angela Risch

Heike Bickeboller

H-Erich Wichmann

Gad Rennert

Susanne Arnold

Paul Brennan

John K Field

Sanjay S Shete

Loic Le Marchand

Geoffrey Liu

Angeline S Andrew

Lambertus A Kiemeney

Shan Zienolddiny

Kjell Grankvist

Mikael Johansson

Neil E Caporaso

Angela Cox

Yun-Chul Hong

Jian-Min Yuan

Matthew B Schabath

Melinda C Aldrich

Meilin Wang

Hongbing Shen

Feng Chen

Zhengdong Zhang

Rayjean J Hung

Christopher I Amos

Qingyi Wei

Philip Lazarus

David C Christiani

Affiliations

Soon will be listed here.

Abstract

Significance: The causal pathway connecting CYP2A6 genetic variability and activity, cigarette consumption, and lung cancer susceptibility in smokers highlights the need for behavior modification interventions based on host susceptibility for cancer prevention.

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