Lambertus A Kiemeney
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Explore the profile of Lambertus A Kiemeney including associated specialties, affiliations and a list of published articles.
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26441
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Recent Articles
1.
Ugalde-Morales E, Wilf R, Pluta J, Ploner A, Fan M, Damra M, et al.
Am J Hum Genet
. 2025 Feb;
112(3):630-643.
PMID: 39999848
Transcriptome-wide association studies (TWASs) have the potential to identify susceptibility genes associated with testicular germ cell tumors (TGCTs). We conducted a comprehensive TGCT TWAS by integrating genome-wide association study (GWAS)...
2.
Allara E, Bell S, Smith R, Keene S, Gill D, Gaziano L, et al.
Commun Biol
. 2024 Dec;
7(1):1631.
PMID: 39643614
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation...
3.
The impact of positive surgical margins after cystectomy on oncological outcomes: a nationwide study
Bosveld J, Nguyen T, Boormans J, Witjes J, van der Heijden A, Mehra N, et al.
BJU Int
. 2024 Dec;
PMID: 39631746
Objective: To evaluate whether surgical margin status, alongside existing postoperative risk indicators, improves the identification of bladder cancer patients who may benefit from adjuvant therapy following radical cystectomy (RC). Methods:...
4.
Pijpers O, van Hoogstraten L, Remmers S, Beijert I, Oddens J, Witjes J, et al.
Eur Urol Oncol
. 2024 Sep;
PMID: 39327188
Patients with high-risk non-muscle-invasive bladder cancer (NMIBC) receive bacillus Calmette-Guérin (BCG) instillations to reduce the risk of progression. For patients with very high-risk NMIBC, immediate radical cystectomy may be considered,...
5.
Hemminki K, Kiemeney L, Morgans A, Ranniko A, Pichler R, Hemminki O, et al.
Eur Urol Open Sci
. 2024 Sep;
69:13-20.
PMID: 39314911
Patient Summary: Tumors of the urogenital tract (prostate, kidney, bladder, and testes) can sometimes be related to genetic mutations that are present in all the cells of the body. Such...
6.
Giraud E, Krens S, Bohringer S, Desar I, Vermeulen S, Kiemeney L, et al.
Br J Clin Pharmacol
. 2024 Aug;
91(2):297-305.
PMID: 39107874
Aims: Sunitinib exhibits considerable interindividual variability in exposure. While the target total plasma concentration of sunitinib and its active metabolite is 50-87.5 ng/mL for the intermittent dosing schedule, ~10-21% of...
7.
van Hoogstraten L, Witjes J, Ripping T, Nooter R, Kiemeney L, Aben K
Bladder Cancer
. 2024 Jul;
7(2):193-203.
PMID: 38994541
Background: EAU guidelines recommend a single instillation (SI) of intravesical chemotherapy (e.g. Mitomycin C) within 24 hours after transurethral resection of a bladder tumour (TURBT) in patients with low- to...
8.
van Hoogstraten L, Kiemeney L, Meijer R, van Leenders G, Vanneste B, Incrocci L, et al.
Bladder Cancer
. 2024 Jul;
8(2):139-154.
PMID: 38993368
Background: The COVID-19 pandemic has disrupted regular health care with potential consequences for non-COVID diseases like cancer. To ensure continuity of oncological care, guidelines were temporarily adapted. Objective: To evaluate...
9.
Blechter B, Wang X, Shi J, Shiraishi K, Choi J, Matsuo K, et al.
medRxiv
. 2024 Jul;
PMID: 38978671
Polygenic risk scores (PRSs) are promising for risk stratification but have mainly been developed in European populations. This study developed single- and multi-ancestry PRSs for lung adenocarcinoma (LUAD) in East...
10.
Dareng E, Coetzee S, Tyrer J, Peng P, Rosenow W, Chen S, et al.
Am J Hum Genet
. 2024 May;
111(6):1061-1083.
PMID: 38723632
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981...