Philip Lazarus
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Explore the profile of Philip Lazarus including associated specialties, affiliations and a list of published articles.
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208
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5730
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Recent Articles
1.
Gaither K, Yue G, Singh D, Trudeau J, Ponraj K, Davydova N, et al.
J Xenobiot
. 2025 Feb;
15(1).
PMID: 39997363
In this study, to better understand the mechanisms of the profound impact of alcohol consumption on drug pharmacokinetics, efficacy, and toxicity, we characterized the alcohol-induced changes in the ensemble of...
2.
Coates S, Bardhi K, Prasad B, Lazarus P
Pharmaceutics
. 2025 Jan;
16(12.
PMID: 39771577
Morphine is a commonly prescribed opioid analgesic used to treat chronic pain. Morphine undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7 to form morphine-3-glucuronide and morphine-6-glucuronide. Morphine is the gold standard for...
3.
Sole-Navais P, Juodakis J, Ytterberg K, Wu X, Bradfield J, Vaudel M, et al.
Nat Commun
. 2024 Aug;
15(1):7550.
PMID: 39214992
Jaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it...
4.
Blechter B, Wang X, Shi J, Shiraishi K, Choi J, Matsuo K, et al.
medRxiv
. 2024 Jul;
PMID: 38978671
Polygenic risk scores (PRSs) are promising for risk stratification but have mainly been developed in European populations. This study developed single- and multi-ancestry PRSs for lung adenocarcinoma (LUAD) in East...
5.
Gaither K, Singh D, Yue G, Trudeau J, Ponraj K, Davydova N, et al.
bioRxiv
. 2024 May;
PMID: 38798409
We examined the effect of alcohol consumption and smoking on the abundance of drug-metabolizing enzymes and transporters (DMET) in human liver microsomes (HLM) isolated from liver tissues of 94 donors....
6.
Zhu J, Branstetter S, Lazarus P, Muscat J
Int J Environ Res Public Health
. 2024 Apr;
21(4).
PMID: 38673313
Background: Low-dose computed tomography (LDCT) increases the early detection of lung cancer. Identifying modifiable behaviors that may affect tumor progression in LDCT-detected patients increases the likelihood of long-term survival and...
7.
Coates S, Bardhi K, Lazarus P
Pharmaceutics
. 2024 Mar;
16(3).
PMID: 38543313
Opioids are commonly prescribed for the treatment of chronic pain. Approximately 50% of adults who are prescribed opioids for pain co-use cannabis with their opioid treatment. Morphine is primarily metabolized...
8.
Bardhi K, Coates S, Chen G, Lazarus P
Pharmaceutics
. 2024 Feb;
16(2).
PMID: 38399297
Benzodiazepines (BZDs) such as oxazepam are commonly prescribed depressant drugs known for their anxiolytic, hypnotic, muscle relaxant, and anticonvulsant effects and are frequently used in conjunction with other illicit drugs...
9.
Wang X, Zhang Z, Ding Y, Chen T, Mucci L, Albanes D, et al.
Genome Med
. 2024 Feb;
16(1):22.
PMID: 38317189
Background: Although polygenic risk score (PRS) has emerged as a promising tool for predicting cancer risk from genome-wide association studies (GWAS), the individual-level accuracy of lung cancer PRS and the...
10.
Sassano M, Taborelli M, Boccia S, Cadoni G, La Vecchia C, Garavello W, et al.
Head Neck
. 2024 Jan;
46(4):926-935.
PMID: 38229229
Background: Aspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Methods: Four...