Tart Cherry ( L.) Pit Extracts Protect Human Skin Cells Against Oxidative Stress: Unlocking Sustainable Uses for Food Industry Byproducts

Overview

Journal Foods

Specialty Biotechnology

Date 2023 Oct 28

PMID 37893640

Authors

Hannah Decot

Meenakshi Sudhakaran

Emma Boismier

Anthony Schilmiller

Ethan Claucherty

Andrea I Doseff

Bahar Aliakbarian

Affiliations

Soon will be listed here.

Abstract

Industrial processing of tart cherries ( L.) produces bioproducts like cherry pits (CP), which contribute to adverse environmental effects. To identify sustainable strategies to minimize the environmental impact of cherry processing, we investigated their potential value as antioxidants for prospective utilization within cosmeceutical applications. Untargeted metabolomic analyses of water and water: ethanol CP extracts using an eco-friendly technique revealed significant enrichment in coumaroyl derivatives and flavonoids with congruent metabolite representation regardless of the extraction solvent. The antioxidant activity of tart CP extracts was evaluated on human skin cells exposed to HO or LPS, modeling environmentally induced oxidants. Notably, both CP extracts provide antioxidant activity by reducing HO or LPS-induced ROS in human skin keratinocytes without affecting cell viability. The CP extracts increased the expression of and genes encoding antioxidant regulatory enzymes while decreasing the expression of , a pro-oxidant regulator. These findings reveal the antioxidant properties of tart CP, offering new opportunities to produce natural-based skin care products and adding economic value while providing sustainable options to reduce the environmental impact of food byproducts.

Citing Articles

From Orchard to Wellness: Unveiling the Health Effects of Sweet Cherry Nutrients.

Goncalves B, Aires A, Oliveira I, Baltazar M, Cosme F, Afonso S Nutrients. 2024; 16(21).

PMID: 39519493 PMC: 11547742. DOI: 10.3390/nu16213660.

References

Re R, Pellegrini N, Proteggente A, Pannala A, Yang M . Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999; 26(9-10):1231-7. DOI: 10.1016/s0891-5849(98)00315-3. View

Singh V, Sahoo D, Agrahari K, Khan A, Mukhopadhyay P, Chanda D . Anti-inflammatory, anti-proliferative and anti-psoriatic potential of apigenin in RAW 264.7 cells, HaCaT cells and psoriasis like dermatitis in BALB/c mice. Life Sci. 2023; 328:121909. DOI: 10.1016/j.lfs.2023.121909. View

Sudhakaran M, Parra M, Stoub H, Gallo K, Doseff A . Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters. Biochem Pharmacol. 2020; 182:114259. PMC: 8020486. DOI: 10.1016/j.bcp.2020.114259. View

Shukitt-Hale B, Kelly M, Bielinski D, Fisher D . Tart Cherry Extracts Reduce Inflammatory and Oxidative Stress Signaling in Microglial Cells. Antioxidants (Basel). 2016; 5(4). PMC: 5187531. DOI: 10.3390/antiox5040033. View

de Almeida A, de Oliveira J, da Silva Pontes L, de Souza Junior J, Goncalves T, Dantas S . ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways. Oxid Med Cell Longev. 2022; 2022:1225578. PMC: 9605829. DOI: 10.1155/2022/1225578. View

Moghe G, Leong B, Hurney S, Jones A, Last R . Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway. Elife. 2017; 6. PMC: 5595436. DOI: 10.7554/eLife.28468. View

Balupillai A, Nagarajan R, Ramasamy K, Govindasamy K, Muthusamy G . Caffeic acid prevents UVB radiation induced photocarcinogenesis through regulation of PTEN signaling in human dermal fibroblasts and mouse skin. Toxicol Appl Pharmacol. 2018; 352:87-96. DOI: 10.1016/j.taap.2018.05.030. View

Peyrol J, Meyer G, Obert P, Dangles O, Pechere L, Amiot M . Involvement of bilitranslocase and beta-glucuronidase in the vascular protection by hydroxytyrosol and its glucuronide metabolites in oxidative stress conditions. J Nutr Biochem. 2017; 51:8-15. DOI: 10.1016/j.jnutbio.2017.09.009. View

Wu W, Chiang H, Fang J, Chen S, Huang C, Hung C . (+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation. Life Sci. 2006; 79(8):801-7. DOI: 10.1016/j.lfs.2006.02.028. View

10.

Krzeminska B, Dybowski M, Klimek K, Typek R, Miazga-Karska M, Dos Santos Szewczyk K . The Anti-Acne Potential and Chemical Composition of Two Cultivated Species. Cells. 2022; 11(3). PMC: 8834067. DOI: 10.3390/cells11030367. View

11.

Agullo-Chazarra L, Borras-Linares I, Lozano-Sanchez J, Segura-Carretero A, Micol V, Herranz-Lopez M . Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties. Antioxidants (Basel). 2020; 9(5). PMC: 7278782. DOI: 10.3390/antiox9050418. View

12.

Thring T, Hili P, Naughton D . Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC Complement Altern Med. 2009; 9:27. PMC: 2728709. DOI: 10.1186/1472-6882-9-27. View

13.

Silva L, Perasoli F, Carvalho K, Vieira K, Lopes M, Souza G . Melaleuca leucadendron (L.) L. flower extract exhibits antioxidant and photoprotective activities in human keratinocytes exposed to ultraviolet B radiation. Free Radic Biol Med. 2020; 159:54-65. DOI: 10.1016/j.freeradbiomed.2020.07.022. View

14.

Peixoto J, Alvarez-Rivera G, Alves R, Costa A, Andrade N, Moreira A . Cherry stem infusions: antioxidant potential and phenolic profile by UHPLC-ESI-QTOF-MS. Food Funct. 2020; 11(4):3471-3482. DOI: 10.1039/c9fo02693b. View

15.

Pollard Z, Goldfarb J . Valorization of cherry pits: Great Lakes agro-industrial waste to mediate Great Lakes water quality. Environ Pollut. 2020; 270:116073. DOI: 10.1016/j.envpol.2020.116073. View

16.

David L, Moldovan B, Baldea I, Olteanu D, Bolfa P, Clichici S . Modulatory effects of Cornus sanguinea L. mediated green synthesized silver nanoparticles on oxidative stress, COX-2/NOS2 and NFkB/pNFkB expressions in experimental inflammation in Wistar rats. Mater Sci Eng C Mater Biol Appl. 2020; 110:110709. DOI: 10.1016/j.msec.2020.110709. View

17.

Taniguchi M, LaRocca C, Bernat J, Lindsey J . Digital Database of Absorption Spectra of Diverse Flavonoids Enables Structural Comparisons and Quantitative Evaluations. J Nat Prod. 2023; 86(4):1087-1119. DOI: 10.1021/acs.jnatprod.2c00720. View

18.

Barbieri R, Coppo E, Marchese A, Daglia M, Sobarzo-Sanchez E, Nabavi S . Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity. Microbiol Res. 2017; 196:44-68. DOI: 10.1016/j.micres.2016.12.003. View

19.

Yilmaz F, Gorguc A, Karaaslan M, Vardin H, Bilek S, Uygun O . Sour Cherry By-products: Compositions, Functional Properties and Recovery Potentials - A Review. Crit Rev Food Sci Nutr. 2018; 59(22):3549-3563. DOI: 10.1080/10408398.2018.1496901. View

20.

Wang H, Nair M, Strasburg G, Booren A, Gray J . Antioxidant polyphenols from tart cherries (Prunus cerasus). J Agric Food Chem. 1999; 47(3):840-4. DOI: 10.1021/jf980936f. View