Dawn of a New Era for Membrane Protein Design

Overview

Journal Biodes Res

Date 2023 Oct 18

PMID 37850134

Authors

Shahin Sowlati-Hashjin

Aanshi Gandhi

Michael Garton

Affiliations

Soon will be listed here.

Abstract

A major advancement has recently occurred in the ability to predict protein secondary structure from sequence using artificial neural networks. This new accessibility to high-quality predicted structures provides a big opportunity for the protein design community. It is particularly welcome for membrane protein design, where the scarcity of solved structures has been a major limitation of the field for decades. Here, we review the work done to date on the membrane protein design and set out established and emerging tools that can be used to most effectively exploit this new access to structures.

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