The Pore Dimensions of Gramicidin A

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 1993 Dec 1

PMID 7508762

Citations 307

Authors

O S Smart

J M Goodfellow

B A Wallace

Affiliations

Soon will be listed here.

Abstract

The ion channel forming peptide gramicidin A adopts a number of distinct conformations in different environments. We have developed a new method to analyze and display the pore dimensions of ion channels. The procedure is applied to two x-ray crystal structures of gramicidin that adopt distinct antiparallel double helical dimer conformations and a nuclear magnetic resonance (NMR) structure for the beta6.3 NH2-terminal to NH2-terminal dimer. The results are discussed with reference to ion conductance properties and dependence of pore dimensions on the environment.

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