Genomics of Treatable Traits in Asthma

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2023 Sep 28

PMID 37761964

Authors

Antonio Espuela-Ortiz

Elena Martin-Gonzalez

Paloma Poza-Guedes

Ruperto Gonzalez-Perez

Esther Herrera-Luis

Affiliations

Soon will be listed here.

Abstract

The astounding number of genetic variants revealed in the 15 years of genome-wide association studies of asthma has not kept pace with the goals of translational genomics. Moving asthma diagnosis from a nonspecific umbrella term to specific phenotypes/endotypes and related traits may provide insights into features that may be prevented or alleviated by therapeutical intervention. This review provides an overview of the different asthma endotypes and phenotypes and the genomic findings from asthma studies using patient stratification strategies and asthma-related traits. Asthma genomic research for treatable traits has uncovered novel and previously reported asthma loci, primarily through studies in Europeans. Novel genomic findings for asthma phenotypes and related traits may arise from multi-trait and specific phenotyping strategies in diverse populations.

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References

Hernandez-Pacheco N, Gorenjak M, Jurgec S, Corrales A, Jorgensen A, Karimi L . Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma. Allergy. 2020; 76(4):1238-1243. PMC: 7908891. DOI: 10.1111/all.14552. View

Tsuo K, Zhou W, Wang Y, Kanai M, Namba S, Gupta R . Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity. Cell Genom. 2023; 2(12):100212. PMC: 9903683. DOI: 10.1016/j.xgen.2022.100212. View

Himmerich H, Fulda S, Linseisen J, Seiler H, Wolfram G, Himmerich S . TNF-alpha, soluble TNF receptor and interleukin-6 plasma levels in the general population. Eur Cytokine Netw. 2006; 17(3):196-201. View

Ortega V, Daya M, Szefler S, Bleecker E, Chinchilli V, Phipatanakul W . Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma. Lancet Child Adolesc Health. 2021; 5(12):862-872. PMC: 8787857. DOI: 10.1016/S2352-4642(21)00268-6. View

Milger K, Gotschke J, Krause L, Nathan P, Alessandrini F, Tufman A . Identification of a plasma miRNA biomarker signature for allergic asthma: A translational approach. Allergy. 2017; 72(12):1962-1971. DOI: 10.1111/all.13205. View

Pividori M, Schoettler N, Nicolae D, Ober C, Im H . Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir Med. 2019; 7(6):509-522. PMC: 6534440. DOI: 10.1016/S2213-2600(19)30055-4. View

Zhu Z, Lee P, Chaffin M, Chung W, Loh P, Lu Q . A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat Genet. 2018; 50(6):857-864. PMC: 5980765. DOI: 10.1038/s41588-018-0121-0. View

Peters M, McGrath K, Hawkins G, Hastie A, Levy B, Israel E . Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016; 4(7):574-584. PMC: 5007068. DOI: 10.1016/S2213-2600(16)30048-0. View

Spear M, Hu D, Pino-Yanes M, Huntsman S, Eng C, Levin A . A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma. Pharmacogenomics J. 2018; 19(3):249-259. PMC: 6414286. DOI: 10.1038/s41397-018-0042-4. View

10.

Boulet L, Lemiere C, Archambault F, Carrier G, Descary M, Deschesnes F . Smoking and asthma: clinical and radiologic features, lung function, and airway inflammation. Chest. 2006; 129(3):661-8. DOI: 10.1378/chest.129.3.661. View

11.

Herrera-Luis E, Mak A, Perez-Garcia J, Martin-Gonzalez E, Eng C, Beckman K . Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth. Thorax. 2022; 78(3):233-241. PMC: 9957797. DOI: 10.1136/thorax-2022-218755. View

12.

Thomson N . Novel approaches to the management of noneosinophilic asthma. Ther Adv Respir Dis. 2016; 10(3):211-34. PMC: 5933607. DOI: 10.1177/1753465816632638. View

13.

Eastman J, Cavagnero K, DeConde A, Kim A, Karta M, Broide D . Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2017; 140(1):101-108.e3. PMC: 5496786. DOI: 10.1016/j.jaci.2016.11.023. View

14.

Kim K, Ober C . Lessons Learned From GWAS of Asthma. Allergy Asthma Immunol Res. 2019; 11(2):170-187. PMC: 6340805. DOI: 10.4168/aair.2019.11.2.170. View

15.

Ricciardolo F, Guida G, Bertolini F, Di Stefano A, Carriero V . Phenotype overlap in the natural history of asthma. Eur Respir Rev. 2023; 32(168). PMC: 10189644. DOI: 10.1183/16000617.0201-2022. View

16.

Foronjy R, DArmiento J . The Effect of Cigarette Smoke-derived Oxidants on the Inflammatory Response of the Lung. Clin Appl Immunol Rev. 2013; 6(1):53-72. PMC: 3755630. DOI: 10.1016/j.cair.2006.04.002. View

17.

Kyriakopoulos C, Gogali A, Bartziokas K, Kostikas K . Identification and treatment of T2-low asthma in the era of biologics. ERJ Open Res. 2021; 7(2). PMC: 8181790. DOI: 10.1183/23120541.00309-2020. View

18.

Ntontsi P, Loukides S, Bakakos P, Kostikas K, Papatheodorou G, Papathanassiou E . Clinical, functional and inflammatory characteristics in patients with paucigranulocytic stable asthma: Comparison with different sputum phenotypes. Allergy. 2017; 72(11):1761-1767. DOI: 10.1111/all.13184. View

19.

Locksley R . Asthma and allergic inflammation. Cell. 2010; 140(6):777-83. PMC: 3134388. DOI: 10.1016/j.cell.2010.03.004. View

20.

Rossios C, Pavlidis S, Hoda U, Kuo C, Wiegman C, Russell K . Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma. J Allergy Clin Immunol. 2017; 141(2):560-570. DOI: 10.1016/j.jaci.2017.02.045. View