Asthma and Allergic Inflammation

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2010 Mar 23

PMID 20303868

Citations 177

Authors

Richard M Locksley

Affiliations

Soon will be listed here.

Abstract

Studies of the initiation and maintenance of asthma and allergic inflammation implicate dysregulated interactions between mucosal epithelia and innate immune cells as the underlying cause of these disorders. The similarities of these responses with mucosal responses to parasitic intestinal worms may reveal pathways relevant to the perplexing rise of these chronic inflammatory disorders.

Citing Articles

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma.

Khan M, Alteneder M, Reiter W, Krausgruber T, Dobnikar L, Madern M Nat Commun. 2025; 16(1):2565.

PMID: 40089475 DOI: 10.1038/s41467-025-57590-3.

The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease.

Wong T, Kang R, Yun K Front Immunol. 2025; 16:1525567.

PMID: 40078995 PMC: 11897520. DOI: 10.3389/fimmu.2025.1525567.

The Late Asthmatic Reaction Is in Part Independent from the Early Asthmatic Reactions.

Zielen S, Alemdar O, Wimmers A, Gronau L, Duecker R, Hutter M Int J Mol Sci. 2025; 26(5).

PMID: 40076712 PMC: 11900439. DOI: 10.3390/ijms26052088.

Hypoxia-inducible factor 2α promotes protective Th2 cell responses during intestinal helminth infection.

Labuda J, Olsen T, Verma S, Kimmel S, Edwards T, Dufort M bioRxiv. 2025; .

PMID: 39868305 PMC: 11761574. DOI: 10.1101/2025.01.09.631414.

Direct activation of toll-like receptor 4 signaling in group 2 innate lymphoid cells contributes to inflammatory responses of allergic diseases.

She L, Alanazi H, Xu Y, Yu Y, Gao Y, Guo S iScience. 2024; 27(11):111240.

PMID: 39563895 PMC: 11574794. DOI: 10.1016/j.isci.2024.111240.

References

Yazdanbakhsh M, Kremsner P, van Ree R . Allergy, parasites, and the hygiene hypothesis. Science. 2002; 296(5567):490-4. DOI: 10.1126/science.296.5567.490. View

Bisgaard H, Hermansen M, Buchvald F, Loland L, Halkjaer L, Bonnelykke K . Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007; 357(15):1487-95. DOI: 10.1056/NEJMoa052632. View

Rogers A, Raby B, Lasky-Su J, Murphy A, Lazarus R, Klanderman B . Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med. 2009; 179(12):1084-90. PMC: 2695495. DOI: 10.1164/rccm.200812-1860OC. View

Burchard E, Ziv E, Coyle N, Gomez S, Tang H, Karter A . The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003; 348(12):1170-5. DOI: 10.1056/NEJMsb025007. View

Maizels R, Pearce E, Artis D, Yazdanbakhsh M, Wynn T . Regulation of pathogenesis and immunity in helminth infections. J Exp Med. 2009; 206(10):2059-66. PMC: 2757871. DOI: 10.1084/jem.20091903. View

Ober C, Tan Z, Sun Y, Possick J, Pan L, Nicolae R . Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med. 2008; 358(16):1682-91. PMC: 2629486. DOI: 10.1056/NEJMoa0708801. View

Seibold M, Reese T, Choudhry S, Salam M, Beckman K, Eng C . Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem. 2009; 284(29):19650-8. PMC: 2740590. DOI: 10.1074/jbc.M109.012443. View

Muller S, Marenholz I, Lee Y, Sengler C, Zitnik S, Griffioen R . Association of Filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population. Pediatr Allergy Immunol. 2009; 20(4):358-61. DOI: 10.1111/j.1399-3038.2008.00808.x. View

Perrigoue J, Saenz S, Siracusa M, Allenspach E, Taylor B, Giacomin P . MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol. 2009; 10(7):697-705. PMC: 2711559. DOI: 10.1038/ni.1740. View

10.

Round J, Mazmanian S . The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009; 9(5):313-23. PMC: 4095778. DOI: 10.1038/nri2515. View

11.

Delmotte P, Sanderson M . Ciliary beat frequency is maintained at a maximal rate in the small airways of mouse lung slices. Am J Respir Cell Mol Biol. 2006; 35(1):110-7. PMC: 2658692. DOI: 10.1165/rcmb.2005-0417OC. View

12.

Moorman J, Anne Rudd R, Johnson C, King M, Minor P, Bailey C . National surveillance for asthma--United States, 1980-2004. MMWR Surveill Summ. 2007; 56(8):1-54. View

13.

Tzeng Y, Lutchen K, Albert M . The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI. J Appl Physiol (1985). 2008; 106(3):813-22. DOI: 10.1152/japplphysiol.01133.2007. View

14.

Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde R, Madan R . Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature. 2008; 457(7229):585-8. PMC: 2843411. DOI: 10.1038/nature07548. View

15.

Niu N, Laufer T, Homer R, Cohn L . Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. J Immunol. 2009; 183(3):1523-7. DOI: 10.4049/jimmunol.0901349. View

16.

Wenzel S . Asthma: defining of the persistent adult phenotypes. Lancet. 2006; 368(9537):804-13. DOI: 10.1016/S0140-6736(06)69290-8. View

17.

Voehringer D, Shinkai K, Locksley R . Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity. 2004; 20(3):267-77. DOI: 10.1016/s1074-7613(04)00026-3. View

18.

Lloyd C, Hawrylowicz C . Regulatory T cells in asthma. Immunity. 2009; 31(3):438-49. PMC: 3385348. DOI: 10.1016/j.immuni.2009.08.007. View

19.

Cortez-Retamozo V, Swirski F, Waterman P, Yuan H, Figueiredo J, Newton A . Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008; 118(12):4058-66. PMC: 2579705. DOI: 10.1172/JCI36335. View

20.

Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y . Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat Immunol. 2009; 10(7):706-12. DOI: 10.1038/ni.1737. View