IgG Antibody Titers Against , , and in Venezuelan Patients with Asthma or COPD

It has been suggested that parasitic infections, common in Latin American populations, may amplify the inflammatory response of the airways. There are several reports of atopic and asthmatic patients but few reports of parasitic infection in COPD patients. This study aimed to determine the prevalence of parasitic infections in COPD patients compared with atopic and asthmatic patients attending the Institute of Immunology outpatient clinics and the pneumology service of the University hospital. A case-control study was conducted compising 100 patients with bronchial asthma, 100 patients with COPD, 100 individuals with atopy without respiratory symptoms, and 100 healthy individuals. Serum-specific IgG antibodies against the parasites (), (), and () were measured by ELISA. IgE levels were used as an indirect indicator of atopy. Positive IgG for was observed in all groups, predominantly in the atopic cohort; positiveness was recorded only in four COPD patients, and positiveness was observed in all groups except in controls. Significant correlations exist between the values of and IgE in controls, atopic, and asthmatic patients without COPD. No correlation was found for . IgE levels and the forced expiratory volume in 1 s (FEV1) correlate only in atopic and asthmatic patients. Parasitic infections are common in atopic patients and moderate and severe asthmatic and COPD patients. Anti-inflammatory treatment may be responsible for the increased frequency of infection in moderate and severe asthmatic and COPD patients.