Influence of Extracellular Vesicles on Lung Stromal Cells During Breast Cancer Metastasis

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 29

PMID 37511559

Authors

Urvi Patel

David Susman

Alison L Allan

Affiliations

Soon will be listed here.

Abstract

Breast cancer is a prominent cause of cancer diagnosis and death in women globally, with over 90% of deaths being attributed to complications that arise from metastasis. One of the common locations for breast cancer metastasis is the lung, which is associated with significant morbidity and mortality. Curative treatments for metastatic breast cancer patients are not available and the molecular mechanisms that underlie lung metastasis are not fully understood. In order to better treat these patients, identifying events that occur both prior to and during metastatic spread to the lung is essential. Several studies have demonstrated that breast cancer-derived extracellular vesicles secreted from the primary breast tumor play a key role in establishing the lung pre-metastatic niche to support colonization of metastatic tumor cells. In this review, we summarize recent work supporting the influence of extracellular vesicles on stromal components of the lung to construct the pre-metastatic niche and support metastasis. Furthermore, we discuss the potential clinical applications of utilizing extracellular vesicles for diagnosis and treatment. Together, this review highlights the dynamic nature of extracellular vesicles, their roles in breast cancer metastasis to the lung, and their value as potential biomarkers and therapeutics for cancer prevention.

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References

Wen H, Brogi E . Lobular Carcinoma In Situ. Surg Pathol Clin. 2018; 11(1):123-145. PMC: 5841603. DOI: 10.1016/j.path.2017.09.009. View

Levental K, Yu H, Kass L, Lakins J, Egeblad M, Erler J . Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009; 139(5):891-906. PMC: 2788004. DOI: 10.1016/j.cell.2009.10.027. View

Bayer S, Grither W, Brenot A, Hwang P, Barcus C, Ernst M . DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs. Elife. 2019; 8. PMC: 6555593. DOI: 10.7554/eLife.45508. View

Shao C, Yang F, Miao S, Liu W, Wang C, Shu Y . Role of hypoxia-induced exosomes in tumor biology. Mol Cancer. 2018; 17(1):120. PMC: 6087002. DOI: 10.1186/s12943-018-0869-y. View

Yang Y, Li C, Chan L, Wei Y, Hsu J, Xia W . Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Res. 2018; 28(8):862-864. PMC: 6082826. DOI: 10.1038/s41422-018-0060-4. View

Han M, Hu J, Lu P, Cao H, Yu C, Li X . Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer. Cell Death Dis. 2020; 11(1):43. PMC: 6976584. DOI: 10.1038/s41419-020-2250-5. View

van der Koog L, Gandek T, Nagelkerke A . Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization. Adv Healthc Mater. 2021; 11(5):e2100639. PMC: 11468589. DOI: 10.1002/adhm.202100639. View

Chu J, Xia Y, Chin-Yee B, Goodale D, Croker A, Allan A . Lung-derived factors mediate breast cancer cell migration through CD44 receptor-ligand interactions in a novel ex vivo system for analysis of organ-specific soluble proteins. Neoplasia. 2014; 16(2):180-91. PMC: 3978398. DOI: 10.1593/neo.132076. View

Chin A, Wang S . Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications. Clin Cancer Res. 2016; 22(15):3725-33. PMC: 4970897. DOI: 10.1158/1078-0432.CCR-16-0028. View

10.

Yang S, Ma S, Dou H, Liu F, Zhang S, Jiang C . Breast cancer-derived exosomes regulate cell invasion and metastasis in breast cancer via miR-146a to activate cancer associated fibroblasts in tumor microenvironment. Exp Cell Res. 2020; 391(2):111983. DOI: 10.1016/j.yexcr.2020.111983. View

11.

Venturella M, Criscuoli M, Carraro F, Naldini A, Zocco D . Interplay between Hypoxia and Extracellular Vesicles in Cancer and Inflammation. Biology (Basel). 2021; 10(7). PMC: 8301089. DOI: 10.3390/biology10070606. View

12.

Wang M, Zhao X, Huang F, Wang L, Huang J, Gong Z . Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications (Review). Int J Oncol. 2021; 58(4). PMC: 7895540. DOI: 10.3892/ijo.2021.5184. View

13.

Jiang H, Zhao H, Zhang M, He Y, Li X, Xu Y . Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects. Front Immunol. 2022; 13:824188. PMC: 9013908. DOI: 10.3389/fimmu.2022.824188. View

14.

Huang H, Shao L, Chen Y, Tang L, Liu T, Li J . Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes-liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer. Bioeng Transl Med. 2022; 7(2):e10284. PMC: 9115690. DOI: 10.1002/btm2.10284. View

15.

Obenauf A, Massague J . Surviving at a Distance: Organ-Specific Metastasis. Trends Cancer. 2017; 1(1):76-91. PMC: 4673677. DOI: 10.1016/j.trecan.2015.07.009. View

16.

Zeng Y, Qiu Y, Jiang W, Shen J, Yao X, He X . Biological Features of Extracellular Vesicles and Challenges. Front Cell Dev Biol. 2022; 10:816698. PMC: 9263222. DOI: 10.3389/fcell.2022.816698. View

17.

Chen W, Hoffmann A, Liu H, Liu X . Organotropism: new insights into molecular mechanisms of breast cancer metastasis. NPJ Precis Oncol. 2018; 2(1):4. PMC: 5871901. DOI: 10.1038/s41698-018-0047-0. View

18.

Gu P, Sun M, Li L, Yang Y, Jiang Z, Ge Y . Breast Tumor-Derived Exosomal MicroRNA-200b-3p Promotes Specific Organ Metastasis Through Regulating CCL2 Expression in Lung Epithelial Cells. Front Cell Dev Biol. 2021; 9:657158. PMC: 8264457. DOI: 10.3389/fcell.2021.657158. View

19.

Donoso-Quezada J, Ayala-Mar S, Gonzalez-Valdez J . The role of lipids in exosome biology and intercellular communication: Function, analytics and applications. Traffic. 2021; 22(7):204-220. PMC: 8361711. DOI: 10.1111/tra.12803. View

20.

Tellez-Gabriel M, Knutsen E, Perander M . Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies. Int J Mol Sci. 2020; 21(24). PMC: 7763984. DOI: 10.3390/ijms21249457. View