Exosomal PD-L1 Harbors Active Defense Function to Suppress T Cell Killing of Breast Cancer Cells and Promote Tumor Growth

Overview

Journal Cell Res

Specialty Cell Biology

Date 2018 Jul 1

PMID 29959401

Citations 268

Authors

Yi Yang

Chia-Wei Li

Li-Chuan Chan

Yongkun Wei

Jung-Mao Hsu

Weiya Xia

Jong-Ho Cha

Junwei Hou

Jennifer L Hsu

Linlin Sun

Mien-Chie Hung

Affiliations

Soon will be listed here.

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References

Quail D, Joyce J . Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013; 19(11):1423-37. PMC: 3954707. DOI: 10.1038/nm.3394. View

Zou W, Wolchok J, Chen L . PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Sci Transl Med. 2016; 8(328):328rv4. PMC: 4859220. DOI: 10.1126/scitranslmed.aad7118. View

Lau J, Cheung J, Navarro A, Lianoglou S, Haley B, Totpal K . Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice. Nat Commun. 2017; 8:14572. PMC: 5321797. DOI: 10.1038/ncomms14572. View

Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G . Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012; 18(6):883-91. PMC: 3645291. DOI: 10.1038/nm.2753. View

Lin H, Wei S, Hurt E, Green M, Zhao L, Vatan L . Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression. J Clin Invest. 2018; 128(2):805-815. PMC: 5785251. DOI: 10.1172/JCI96113. View

Curiel T, Wei S, Dong H, Alvarez X, Cheng P, Mottram P . Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med. 2003; 9(5):562-7. DOI: 10.1038/nm863. View

Smith-Garvin J, Koretzky G, Jordan M . T cell activation. Annu Rev Immunol. 2009; 27:591-619. PMC: 2740335. DOI: 10.1146/annurev.immunol.021908.132706. View

Milane L, Singh A, Mattheolabakis G, Suresh M, Amiji M . Exosome mediated communication within the tumor microenvironment. J Control Release. 2015; 219:278-294. DOI: 10.1016/j.jconrel.2015.06.029. View

Saunders P, Hendrycks V, Lidinsky W, Woods M . PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. Eur J Immunol. 2005; 35(12):3561-9. DOI: 10.1002/eji.200526347. View

10.

Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H . Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity. Nat Immunol. 2013; 14(8):793-803. DOI: 10.1038/ni.2647. View

11.

Zhang H, Deng T, Liu R, Bai M, Zhou L, Wang X . Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis. Nat Commun. 2017; 8:15016. PMC: 5394240. DOI: 10.1038/ncomms15016. View

12.

Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A . Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2009; 12(1):19-30. DOI: 10.1038/ncb2000. View

13.

Theodoraki M, Yerneni S, Hoffmann T, Gooding W, Whiteside T . Clinical Significance of PD-L1 Exosomes in Plasma of Head and Neck Cancer Patients. Clin Cancer Res. 2017; 24(4):896-905. PMC: 6126905. DOI: 10.1158/1078-0432.CCR-17-2664. View

14.

Bobrie A, Krumeich S, Reyal F, Recchi C, Moita L, Seabra M . Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res. 2012; 72(19):4920-30. DOI: 10.1158/0008-5472.CAN-12-0925. View