Linoleic and Arachidonic Fatty Acids and Their Potential Relationship with Inflammation, Pregnancy, and Fetal Development

Overview

Journal Curr Med Chem

Publisher Bentham Science Publishers

Specialty Chemistry

Date 2023 Jul 7

PMID 37415369

Authors

Macarena Ortiz

Daniela Alvarez

Yasna Munoz

Nicolas Crisosto

Rodrigo Valenzuela

Manuel Maliqueo

Affiliations

Soon will be listed here.

Abstract

Objective: To summarize the evidence of maternal, placental, and fetal alterations that an excessive intake of n-6 polyunsaturated FAs (PUFAs), LA, and AA, could produce during pregnancy.

Methods: A thorough review of the literature regarding the effects of n-6 PUFAs during pregnancy and lactation including and models, was carried out using the PubMed database from the National Library of Medicine-National Institutes of Health.

Results: An elevated intake of n-6 PUFA, specifically LA, during pregnancy influences children's motor, cognitive, and verbal development during infancy and early childhood. Similarly, they could harm the placenta and the development of other fetal organs such as the fat tissue, liver, and cardiovascular system.

Conclusion: Maternal diet, specifically LA intake, could have significant repercussions on fetal development and long-term consequences in the offspring, including the possibility of future metabolic and mental diseases. It would be necessary to focus on the prevention of these alterations through timely dietary interventions in the target population.

Citing Articles

Sex-Specific Changes to Brain Fatty Acids, Plasmalogen, and Plasma Endocannabinoids in Offspring Exposed to Maternal and Postnatal High-Linoleic-Acid Diets.

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PMID: 39063152 PMC: 11277558. DOI: 10.3390/ijms25147911.

Maternal Diet High in Linoleic Acid Alters Renal Branching Morphogenesis and mTOR/AKT Signalling Genes in Rat Fetal Kidneys.

McClelland C, Holland O, Shrestha N, Jukes C, Brandon A, Cuffe J Int J Mol Sci. 2024; 25(9).

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The Effect of Maternal Exposure to a Diet High in Fats and Cholesterol on the Placental Function and Phenotype of the Offspring in a Rabbit Model: A Summary Review of About 15 Years of Research.

Rousseau-Ralliard D, Chavatte-Palmer P, Couturier-Tarrade A Int J Mol Sci. 2023; 24(19).

PMID: 37834002 PMC: 10572169. DOI: 10.3390/ijms241914547.

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