Hepatic Glycogen Synthesis on Carbohydrate Re-feeding After Starvation. A Regulatory Role for Pyruvate Dehydrogenase in Liver and Extrahepatic Tissues

Overview

Journal Biochem J

Specialty Biochemistry

Date 1986 Apr 15

PMID 3741401

Citations 28

Authors

M J Holness

T J French

M C Sugden

Affiliations

Soon will be listed here.

Abstract

Glucose administration to 48 h-starved rats increased hepatic glucose, lactate, pyruvate and glycogen concentrations and re-activated PDH (pyruvate dehydrogenase complex) in kidney, but not in heart or liver. Dichloroacetate together with glucose re-activated PDH in all three tissues, decreased hepatic lactate and pyruvate concentrations and impaired glycogen resynthesis. Thus on re-feeding, delayed PDH re-activation is important for provision of precursors for hepatic glyconeogenesis.

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Evidence for the adverse effect of starvation on bone quality: a review of the literature.

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Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart.

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