Comparison of Tissue Pyruvate Dehydrogenase Activities on Re-feeding Rats Fed Ad Libitum or Meal-fed Rats with a Chow-diet Meal

Overview

Journal Biochem J

Specialty Biochemistry

Date 1989 Aug 15

PMID 2818570

Citations 6

Authors

M J Holness

M C Sugden

Affiliations

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Abstract

Meal-fed rats and rats fed ad libitum had similar rates of hepatic glycogenesis at 60 min after the initiation of re-feeding a chow meal after 22 h starvation, but hepatic PDHa (active form of pyruvate dehydrogenase) activities were 4-fold higher in the meal-fed group. In heart, PDHa activities were 3-fold higher before re-feeding and 2-fold higher after re-feeding in the meal-fed group compared with the group fed ad lib. The blood metabolite profile suggested diminished fat oxidation in starved meal-fed rats and accelerated flux through PDH in meal-fed re-fed rats compared with the group fed ad lib.

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