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Phosphorylation of Additional Sites on Pyruvate Dehydrogenase Inhibits Its Re-activation by Pyruvate Dehydrogenase Phosphate Phosphatase

Overview
Journal Biochem J
Specialty Biochemistry
Date 1978 Feb 1
PMID 204298
Citations 27
Authors
P H Sugden
N J Hutson
A L Kerbey
P J Randle
Affiliations
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Abstract

The phosphorylation of sites additional to an inactivating site inhibits the formation of active pig heart pyruvate dehydrogenase complex from inactive pyruvate dehydrogenase phosphate complex by pig heart pyruvate dehydrogenase phosphate phosphatase.

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References
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Kerbey A, Randle P, Cooper R, Whitehouse S, Pask H, Denton R . Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A.... Biochem J. 1976; 154(2):327-48. PMC: 1172714. DOI: 10.1042/bj1540327. View
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Kerbey A, Radcliffe P, Randle P . Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A. Biochem J. 1977; 164(3):509-19. PMC: 1164826. DOI: 10.1042/bj1640509. View
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Davis P, Pettit F, Reed L . Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase. Biochem Biophys Res Commun. 1977; 75(3):541-9. DOI: 10.1016/0006-291x(77)91506-6. View
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Cooper R, Randle P, Denton R . Regulation of heart muscle pyruvate dehydrogenase kinase. Biochem J. 1974; 143(3):625-41. PMC: 1168432. DOI: 10.1042/bj1430625. View
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Severson D, Denton R, Pask H, Randle P . Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase. Biochem J. 1974; 140(2):225-37. PMC: 1167994. DOI: 10.1042/bj1400225. View