Skeletal-muscle Glycogen Synthesis During the Starved-to-fed Transition in the Rat

Overview

Journal Biochem J

Specialty Biochemistry

Date 1988 Sep 15

PMID 3196298

Citations 8

Authors

M J Holness

M C Sugden

Affiliations

Soon will be listed here.

Abstract

The pattern of glycogen deposition in skeletal muscles of varying fibre composition was examined in rats during the starved-to-fed transition. In all the muscles studied, glycogen concentrations steadily increased during the first 8 h after chow re-feeding, and the fed value was exceeded. Rates of glycogen deposition varied, not with muscle fibre composition, but with the extent of glycogen depletion during starvation. There was no evidence for skeletal-muscle glycogen breakdown during the period of hepatic glycogenesis, making it unlikely that recycling of carbon from muscle glycogen to lactate is quantitatively important for the provision of glycogenic precursors to the liver, but moderate glycogen loss was observed from 8 to 24 h after re-feeding, when the liver is in the lipogenic mode. The factors influencing glucose disposal by skeletal muscle after re-feeding are discussed.

Citing Articles

Re-feeding after starvation involves a temporal shift in the control site of glycogen synthesis in rat muscle.

James A, Flynn C, Jones S, Palmer T, Fournier P Biochem J. 1998; 329 ( Pt 2):341-7.

PMID: 9425118 PMC: 1219050. DOI: 10.1042/bj3290341.

Effects of re-feeding after prolonged starvation on pyruvate dehydrogenase activities in heart, diaphragm and selected skeletal muscles of the rat.

Sugden M, Holness M Biochem J. 1989; 262(2):669-72.

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Fuel selection and carbon flux during the starved-to-fed transition.

Sugden M, Holness M, Palmer T Biochem J. 1989; 263(2):313-23.

PMID: 2688629 PMC: 1133432. DOI: 10.1042/bj2630313.

Glucose utilization and disposal in cardiothoracic and skeletal muscles during the starved-to-fed transition in the rat.

Sugden M, Liu Y, Holness M Biochem J. 1990; 272(1):133-7.

PMID: 2264816 PMC: 1149667. DOI: 10.1042/bj2720133.

Initial glucose kinetics and hormonal response to a gastric glucose load in unrestrained post-absorptive and starved rats.

Smadja C, Morin J, Ferre P, Girard J Biochem J. 1990; 270(2):505-10.

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References

Terjung R, Baldwin K, Winder W, Holloszy J . Glycogen repletion in different types of muscle and in liver after exhausting exercise. Am J Physiol. 1974; 226(6):1387-91. DOI: 10.1152/ajplegacy.1974.226.6.1387. View

Holness M, MacLennan P, Palmer T, Sugden M . The disposition of carbohydrate between glycogenesis, lipogenesis and oxidation in liver during the starved-to-fed transition. Biochem J. 1988; 252(2):325-30. PMC: 1149147. DOI: 10.1042/bj2520325. View

Conlee R, Hickson R, Winder W, Hagberg J, Holloszy J . Regulation of glycogen resynthesis in muscles of rats following exercise. Am J Physiol. 1978; 235(3):R145-50. DOI: 10.1152/ajpregu.1978.235.3.R145. View

Shikama H, Ui M . Glucose load diverts hepatic gluconeogenic product from glucose to glycogen in vivo. Am J Physiol. 1978; 235(4):E354-60. DOI: 10.1152/ajpendo.1978.235.4.E354. View

Le Marchand-Brustel Y, Freychet P . Effect of fasting and streptozotocin diabetes on insulin binding and action in the isolated mouse soleus muscle. J Clin Invest. 1979; 64(5):1505-15. PMC: 371300. DOI: 10.1172/JCI109609. View

Brady L, Goodman M, Kalish F, Ruderman N . Insulin binding and sensitivity in rat skeletal muscle: effect of starvation. Am J Physiol. 1981; 240(2):E184-90. DOI: 10.1152/ajpendo.1981.240.2.E184. View

Fell R, Terblanche S, Ivy J, Young J, Holloszy J . Effect of muscle glycogen content on glucose uptake following exercise. J Appl Physiol Respir Environ Exerc Physiol. 1982; 52(2):434-7. DOI: 10.1152/jappl.1982.52.2.434. View

Abumrad N, Cherrington A, Williams P, LACY W, Rabin D . Absorption and disposition of a glucose load in the conscious dog. Am J Physiol. 1982; 242(6):E398-406. DOI: 10.1152/ajpendo.1982.242.6.E398. View

Goodman M, Lowell B, Ruderman N . Protein conservation during starvation: possible role of lipid fuels. Prog Clin Biol Res. 1982; 102 Pt C:317-31. View

10.

Preedy V, Garlick P . Protein synthesis in skeletal muscle of the perfused rat hemicorpus compared with rates in the intact animal. Biochem J. 1983; 214(2):433-42. PMC: 1152264. DOI: 10.1042/bj2140433. View

11.

Newgard C, Foster D, McGarry J . Evidence for suppression of hepatic glucose-6-phosphatase with carbohydrate feeding. Diabetes. 1984; 33(2):192-5. DOI: 10.2337/diab.33.2.192. View

12.

Bjorkman O, Crump M, Phillips R . Intestinal metabolism of orally administered glucose and fructose in Yucatan miniature swine. J Nutr. 1984; 114(8):1413-20. DOI: 10.1093/jn/114.8.1413. View

13.

Stirewalt W, Low R, Slaiby J . Insulin sensitivity and responsiveness of epitrochlearis and soleus muscles from fed and starved rats. Recognition of differential changes in insulin sensitivities of protein synthesis and glucose incorporation into glycogen. Biochem J. 1985; 227(2):355-62. PMC: 1144853. DOI: 10.1042/bj2270355. View

14.

Zorzano A, Balon T, Brady L, Rivera P, Garetto L, Young J . Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle. Biochem J. 1985; 232(2):585-91. PMC: 1152919. DOI: 10.1042/bj2320585. View

15.

Holness M, French T, Sugden M . Hepatic glycogen synthesis on carbohydrate re-feeding after starvation. A regulatory role for pyruvate dehydrogenase in liver and extrahepatic tissues. Biochem J. 1986; 235(2):441-5. PMC: 1146706. DOI: 10.1042/bj2350441. View

16.

Hellerstein M, Greenblatt D, MUNRO H . Glycoconjugates as noninvasive probes of intrahepatic metabolism: pathways of glucose entry into compartmentalized hepatic UDP-glucose pools during glycogen accumulation. Proc Natl Acad Sci U S A. 1986; 83(18):7044-8. PMC: 386649. DOI: 10.1073/pnas.83.18.7044. View

17.

Penicaud L, Ferre P, Kande J, Leturque A, Issad T, Girard J . Effect of anesthesia on glucose production and utilization in rats. Am J Physiol. 1987; 252(3 Pt 1):E365-9. DOI: 10.1152/ajpendo.1987.252.3.E365. View

18.

McGarry J, Kuwajima M, Newgard C, Foster D, Katz J . From dietary glucose to liver glycogen: the full circle round. Annu Rev Nutr. 1987; 7:51-73. DOI: 10.1146/annurev.nu.07.070187.000411. View

19.

Bartels H, Vogt B, Jungermann K . Glycogen synthesis from pyruvate in the periportal and from glucose in the perivenous zone in perfused livers from fasted rats. FEBS Lett. 1987; 221(2):277-83. DOI: 10.1016/0014-5793(87)80940-7. View

20.

Hue L, Rider M . Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues. Biochem J. 1987; 245(2):313-24. PMC: 1148124. DOI: 10.1042/bj2450313. View