Functional Heterogeneity of Human Skin-resident Memory T Cells in Health and Disease

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2023 May 5

PMID 37144705

Authors

Johanna Strobl

Muzlifah Haniffa

Affiliations

Soon will be listed here.

Abstract

The human skin is populated by a diverse pool of memory T cells, which can act rapidly in response to pathogens and cancer antigens. Tissue-resident memory T cells (T ) have been implicated in range of allergic, autoimmune and inflammatory skin diseases. Clonal expansion of cells with T properties is also known to contribute to cutaneous T-cell lymphoma. Here, we review the heterogeneous phenotypes, transcriptional programs, and effector functions of skin T . We summarize recent studies on T formation, longevity, plasticity, and retrograde migration and contextualize the findings to skin T and their role in maintaining skin homeostasis and altered functions in skin disease.

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