Memory T Cells in Nonlymphoid Tissue That Provide Enhanced Local Immunity During Infection with Herpes Simplex Virus

Overview

Journal Nat Immunol

Date 2009 Mar 24

PMID 19305395

Citations 667

Authors

Thomas Gebhardt

Linda M Wakim

Liv Eidsmo

Patrick C Reading

William R Heath

Francis R Carbone

Affiliations

Soon will be listed here.

Abstract

Effective immunity is dependent on long-surviving memory T cells. Various memory subsets make distinct contributions to immune protection, especially in peripheral infection. It has been suggested that T cells in nonlymphoid tissues are important during local infection, although their relationship with populations in the circulation remains poorly defined. Here we describe a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia. These T cells were in disequilibrium with the circulating lymphocyte pool and controlled new infection with this virus. Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry.

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