1,4-Dihydropyridines As Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis

Overview

Journal ACS Catal

Publisher American Chemical Society

Date 2016 Dec 20

PMID 27990318

Citations 50

Authors

Alvaro Gutierrez-Bonet

John C Tellis

Jennifer K Matsui

Brandon A Vara

Gary A Molander

Affiliations

Soon will be listed here.

Abstract

A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to C-centered alkyl radical coupling partners. The reported method is characterized by its extremely mild reaction conditions, enabling access to underexplored cores.

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