Rat Placentation: an Experimental Model for Investigating the Hemochorial Maternal-fetal Interface

Overview

Journal Placenta

Publisher Elsevier

Specialties Gynecology & Obstetrics
Physiology
Reproductive Medicine

Date 2012 Jan 31

PMID 22284666

Citations 102

Authors

M J Soares

D Chakraborty

M A Karim Rumi

T Konno

S J Renaud

Affiliations

Soon will be listed here.

Abstract

The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-directed uterine spiral artery remodeling; features shared with human placentation. Recognition of these similarities spurred the establishment of in vitro and in vivo research methods using the rat as an animal model to address mechanistic questions regarding development of the hemochorial placenta. The purpose of this review is to provide the requisite background to help move the rat to the forefront in placentation research.

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