Serum Vitamin D Status and Circulating Irisin Levels in Older Adults with Sarcopenia

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Dec 26

PMID 36570156

Authors

Yawen Wang

Yeqing Gu

Jian Huang

Hongmei Wu

Ge Meng

Qing Zhang

Li Liu

Shunming Zhang

Xuena Wang

Juanjuan Zhang

Shaomei Sun

Xing Wang

Ming Zhou

Qiyu Jia

Kun Song

Junsheng Huo

Bing Zhang

Gangqiang Ding

Peng Du

Kaijun Niu

Affiliations

Soon will be listed here.

Abstract

Background: Emerging evidence suggests sarcopenia, which is involved in the serum vitamin D deficiency and development of abnormal muscle metabolism, is predominately centered in the general older population. In the present study, we aimed to explore the relationship between the level of serum vitamin D and irisin concentrations in the older adults with sarcopenia.

Methods: A cross-sectional study was conducted which included 422 sarcopenia participants (146 males and 276 females). Sarcopenia was assessed according to the recommended diagnostic criteria of the Asia Working Group for Sarcopenia (AWGS). The levels of serum 25-hydroxyvitamin D (25(OH)D), 25-hydroxyvitamin D (25(OH)D) and 25-hydroxyvitamin D (25(OH)D) were determined by LC-MS/MS. Irisin levels were measured by enzyme-linked immunosorbent assay (ELISA). The relationship between serum concentration of vitamin D and irisin were determined using multiple linear regression analysis.

Results: After adjustment for potential confounding factors, a significant and positive relationship between changes in irisin across 25(OH)D, and 25(OH)D was observed (standard regression coefficients of 0.150 and 0.151, respectively, < 0.05). However, no significant relationship was observed between serum vitamin D concentrations and irisin levels in males.

Conclusions: This study demonstrated that a higher level of serum vitamin D is independently related to the increment of irisin in sarcopenia females, not in males. These investigations need to be verified in other large-scale prospective studies.

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