Associations Between Total, Free and Bioavailable 25-hydroxyvitamin D Forms with Adiponectin and Irisin in Maternal-neonatal Pairs at Birth from Greece

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2024 Jul 22

PMID 39036056

Authors

Tarek Ziad Arabi

Hana M A Fakhoury

Hani Tamim

Rene F Chun

Martin Hewison

Fatme AlAnouti

Stefan Pilz

Cedric Annweiler

Georgios Tzimagiorgis

Costas Haitoglou

Spyridon N Karras

Affiliations

Soon will be listed here.

Abstract

Background: Apart from the well-established skeletal effects, itamin D has been explored as a secretagogue influencing various adipokines, including adiponectin and irisin. Recent evidence suggests that specific forms of 25-Hydroxyvitamin D (25(OHD), such as free and bioavailable 25(OH)D, may provide more accurate measurements of vitamin D status. The relationship between vitamin D status and serum irisin and adiponectin concentrations remains largely unexplored, particularly during pregnancy.

Methods: We analyzed data from 67 healthy maternal-neonatal pairs from Northern Greece at birth. Biochemical and hormonal tests were conducted on each maternal-neonatal pair. The vitamin D forms were estimated using validated mathematical models. Subsequently, regression analyses were conducted to determine the association between the vitamin D forms and adipokine levels.

Results: Bioavailable maternal 25(OH)D was inversely associated with neonatal irisin concentrations [β=-73.46 (-140.573 to -6.341), p=0.034]. No other associations were observed between maternal vitamin D status and neonatal adipokine concentrations.

Conclusion: In conclusion, maternal bioavailable vitamin D concentrations are inversely associated with neonatal serum irisin concentrations, warranting further studies to evaluate the underlying mechanisms for this finding.

References

Sanesi L, Dicarlo M, Pignataro P, Zerlotin R, Pugliese F, Columbu C . Vitamin D Increases Irisin Serum Levels and the Expression of Its Precursor in Skeletal Muscle. Int J Mol Sci. 2023; 24(4). PMC: 9963830. DOI: 10.3390/ijms24044129. View

Fang H, Judd R . Adiponectin Regulation and Function. Compr Physiol. 2018; 8(3):1031-1063. DOI: 10.1002/cphy.c170046. View

Karras S, Polyzos S, Newton D, Wagner C, Hollis B, Van den Ouweland J . Adiponectin and vitamin D-binding protein are independently associated at birth in both mothers and neonates. Endocrine. 2017; 59(1):164-174. DOI: 10.1007/s12020-017-1475-2. View

Luo Y, Qiao X, Xu L, Huang G . Irisin: circulating levels in serum and its relation to gonadal axis. Endocrine. 2022; 75(3):663-671. PMC: 8888466. DOI: 10.1007/s12020-022-02981-5. View

Zhang Z, Lu Q, Huang J, Jiao C, Huang S, Mao L . Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study. BMC Pregnancy Childbirth. 2016; 16(1):189. PMC: 4962456. DOI: 10.1186/s12884-016-0978-9. View

Arabi T, Shafqat A, Sabbah B, Fawzy N, Shah H, Abdulkader H . Obesity-related kidney disease: Beyond hypertension and insulin-resistance. Front Endocrinol (Lausanne). 2023; 13:1095211. PMC: 9884830. DOI: 10.3389/fendo.2022.1095211. View

Wang Y, Gu Y, Huang J, Wu H, Meng G, Zhang Q . Serum vitamin D status and circulating irisin levels in older adults with sarcopenia. Front Nutr. 2022; 9:1051870. PMC: 9768190. DOI: 10.3389/fnut.2022.1051870. View

Karras S, Koufakis T, Fakhoury H, Kotsa K . Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge. Front Endocrinol (Lausanne). 2018; 9:259. PMC: 5974103. DOI: 10.3389/fendo.2018.00259. View

Karras S, Dursun E, Alaylioglu M, Gezen-Ak D, Al Anouti F, Pilz S . Upregulation of Irisin and Vitamin D-Binding Protein Concentrations by Increasing Maternal 25-Hydrovitamin D Concentrations in Combination with Specific Genotypes of Vitamin D-Binding Protein Polymorphisms. Nutrients. 2022; 14(1). PMC: 8746495. DOI: 10.3390/nu14010090. View

10.

Safarpour P, Daneshi-Maskooni M, Vafa M, Nourbakhsh M, Janani L, Maddah M . Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial. BMC Fam Pract. 2020; 21(1):26. PMC: 7007689. DOI: 10.1186/s12875-020-1096-3. View

11.

Shan D, Liu X, Cai Y, Qiao X, Xu L, Zou L . Irisin level and neonatal birthweight: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2020; 254:25-32. DOI: 10.1016/j.ejogrb.2020.08.045. View

12.

Markopoulou P, Koutroumpa A, Mantzou A, Margeli A, Papanikolaou E, Siahanidou T . Association of Plasma Irisin Levels with Circulating Endothelial Microparticles (EMPs) and Endothelial Progenitor Cells (EPCs) in Children Born Prematurely. Metabolites. 2023; 13(1). PMC: 9861173. DOI: 10.3390/metabo13010120. View

13.

Safari S, Rafraf M, Malekian M, Molani-Gol R, Asghari-Jafarabadi M, Mobasseri M . Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial. Front Endocrinol (Lausanne). 2024; 14:1306470. PMC: 10764604. DOI: 10.3389/fendo.2023.1306470. View

14.

Rashid F, Abbas H, Naser N, Addai Ali H . Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men. ScientificWorldJournal. 2020; 2020:1897027. PMC: 7481929. DOI: 10.1155/2020/1897027. View

15.

Fernando M, Coster T, Ellery S, de Guingand D, Lim S, Harrison C . Relationships between Total, Free and Bioavailable Vitamin D and Vitamin D Binding Protein in Early Pregnancy with Neonatal Outcomes: A Retrospective Cohort Study. Nutrients. 2020; 12(9). PMC: 7551024. DOI: 10.3390/nu12092495. View

16.

Faienza M, Brunetti G, Grugni G, Fintini D, Convertino A, Pignataro P . The genetic background and vitamin D supplementation can affect irisin levels in Prader-Willi syndrome. J Endocrinol Invest. 2021; 44(10):2261-2271. PMC: 8421289. DOI: 10.1007/s40618-021-01533-4. View

17.

Demirel S, Ozyener F . Irisin Relaxes Rat Trachea via K Channels, K Channels, and BK Channels. Protein Pept Lett. 2022; 29(9):760-768. DOI: 10.2174/0929866529666220729115541. View

18.

Yeung E, McLain A, Anderson N, Lawrence D, Boghossian N, Druschel C . Newborn Adipokines and Birth Outcomes. Paediatr Perinat Epidemiol. 2015; 29(4):317-25. PMC: 4484786. DOI: 10.1111/ppe.12203. View

19.

Nikooyeh B, Neyestani T . Can vitamin D be considered an adiponectin secretagogue? A systematic review and meta-analysis. J Steroid Biochem Mol Biol. 2021; 212:105925. DOI: 10.1016/j.jsbmb.2021.105925. View

20.

Turkes G, Uysal S, Demir T, Demiral Y, Pamuk B, Yilmaz H . Associations Between Bioavailable Vitamin D and Remnant Cholesterol in Patients With Type 2 Diabetes Mellitus. Cureus. 2021; 13(2):e13248. PMC: 7948319. DOI: 10.7759/cureus.13248. View