Weil's Disease-Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2022 Dec 23

PMID 36551258

Authors

Pavlo Petakh

Vitaliia Isevych

Aleksandr Kamyshnyi

Valentyn Oksenych

Affiliations

Soon will be listed here.

Abstract

Leptospirosis is an important zoonotic disease, causing about 60,000 deaths annually. In this review, we have described in detail the immunopathogenesis of leptospirosis, the influence of cytokines, genetic susceptibility on the course of the disease, and the evasion of the immune response. These data are combined with information about immunological and pathomorphological changes in the kidneys, liver, and lungs, which are most affected by Weil's disease. The review also suggests a possible role of the gut microbiota in the clinical course of leptospirosis, the main mechanisms of the influence of gut dysbiosis on damage in the liver, kidneys, and lungs through several axes, i.e., gut-liver, gut-kidney, and gut-lungs. Modulation of gut microbiota by probiotics and/or fecal microbiota transplantation in leptospirosis may become an important area of scientific research.

Citing Articles

Oliguria as a diagnostic marker of severe leptospirosis: a study from the Transcarpathian region of Ukraine.

Petakh P, Kamyshnyi O Front Cell Infect Microbiol. 2024; 14:1467915.

PMID: 39544281 PMC: 11560875. DOI: 10.3389/fcimb.2024.1467915.

Investigation of Leptospirosis Agents in Cattle and Humans.

Bagatir P, Aktas O Malays J Med Sci. 2024; 31(5):151-160.

PMID: 39416737 PMC: 11477467. DOI: 10.21315/mjms2024.31.5.11.

Impact of Antibiotic and Steroid Therapy on Leptospirosis Outcomes: A Retrospective Cohort Study in Transcarpathia, Ukraine.

Petakh P, Poliak M, Kohutych A, Oksenych V, Kamyshnyi O Biomedicines. 2024; 12(8).

PMID: 39200150 PMC: 11352182. DOI: 10.3390/biomedicines12081685.

Corticosteroid Treatment for Leptospirosis: A Systematic Review and Meta-Analysis.

Petakh P, Oksenych V, Kamyshnyi O J Clin Med. 2024; 13(15).

PMID: 39124577 PMC: 11313367. DOI: 10.3390/jcm13154310.

Comprehensive Analysis of Antiphage Defense Mechanisms: Serovar-Specific Patterns.

Petakh P, Oksenych V, Khovpey Y, Kamyshnyi O Antibiotics (Basel). 2024; 13(6).

PMID: 38927188 PMC: 11201134. DOI: 10.3390/antibiotics13060522.

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