» Articles » PMID: 39200150

Impact of Antibiotic and Steroid Therapy on Leptospirosis Outcomes: A Retrospective Cohort Study in Transcarpathia, Ukraine

Overview
Journal Biomedicines
Date 2024 Aug 29
PMID 39200150
Authors
Affiliations
Soon will be listed here.
Abstract

Leptospirosis presents a significant health challenge in the Transcarpathian region of Ukraine, with higher incidence rates and mortality compared to national averages. We conducted a retrospective cohort study to investigate the effects of antibiotic and steroid treatments on outcomes in leptospirosis patients. Our analysis of clinical and laboratory data from a single center revealed that dexamethasone showed significant effects on various clinical variables, as did investigated antibiotics. Notable differences in clinical and laboratory outcomes were observed, particularly in direct bilirubin levels, which were significantly higher in non-survivors. ROC analysis demonstrated high sensitivity and specificity of direct bilirubin as a predictor of mortality. These findings highlight the importance of targeted treatment strategies and the potential of specific laboratory markers in improving leptospirosis management.

Citing Articles

Geographical factors and air raid alarms influence leptospirosis epidemiology in Ukraine (2018-2023).

Petakh P, Huber W, Kamyshnyi O One Health. 2024; 19:100944.

PMID: 39679281 PMC: 11639380. DOI: 10.1016/j.onehlt.2024.100944.

References
1.
Doudier B, Garcia S, Quennee V, Jarno P, Brouqui P . Prognostic factors associated with severe leptospirosis. Clin Microbiol Infect. 2006; 12(4):299-300. DOI: 10.1111/j.1469-0691.2005.01335.x. View

2.
Petakh P, Kamyshnyi A, Tymchyk V, Armitage R . Infectious diseases during the Russian-Ukrainian war - Morbidity in the Transcarpathian region as a marker of epidemic danger on the EU border. Public Health Pract (Oxf). 2023; 6:100397. PMC: 10336168. DOI: 10.1016/j.puhip.2023.100397. View

3.
Brinker A, Blazes D . An outbreak of Leptospirosis among United States military personnel in Guam. Trop Dis Travel Med Vaccines. 2017; 3:16. PMC: 5661914. DOI: 10.1186/s40794-017-0059-8. View

4.
Jansen A, Stark K, Schneider T, Schoneberg I . Sex differences in clinical leptospirosis in Germany: 1997-2005. Clin Infect Dis. 2007; 44(9):e69-72. DOI: 10.1086/513431. View

5.
Limothai U, Lumlertgul N, Sirivongrangson P, Kulvichit W, Tachaboon S, Dinhuzen J . The role of leptospiremia and specific immune response in severe leptospirosis. Sci Rep. 2021; 11(1):14630. PMC: 8285422. DOI: 10.1038/s41598-021-94073-z. View