Focus on the Gut-Kidney Axis in Health and Disease

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2021 Feb 8

PMID 33553216

Citations 35

Authors

Elisavet Stavropoulou

Konstantia Kantartzi

Christina Tsigalou

Theoharis Konstantinidis

Gioulia Romanidou

Chrysa Voidarou

Eugenia Bezirtzoglou

Affiliations

Soon will be listed here.

Abstract

The recent new developments in technology with culture-independent techniques including genome sequencing methodologies shed light on the identification of microbiota bacterial species and their role in health and disease. Microbiome is actually reported as an important predictive tool for evaluating characteristic shifts in case of disease. Our present review states the development of different renal diseases and pathologies linked to the intestinal dysbiosis, which impacts on host homeostasis. The gastrointestinal-kidney dialogue provides intriguing features in the pathogenesis of several renal diseases. Without any doubt, investigation of this interconnection consists one of the most cutting-edge areas of research with potential implications on our health.

Citing Articles

Effects of Dietary Fiber Supplementation on Modulating Uremic Toxins and Inflammation in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Wathanavasin W, Cheungpasitporn W, Thongprayoon C, Fulop T Toxins (Basel). 2025; 17(2).

PMID: 39998074 PMC: 11860371. DOI: 10.3390/toxins17020057.

Lifestyle Factors and the Microbiome in Urolithiasis: A Narrative Review.

Koudonas A, Tsiakaras S, Tzikoulis V, Papaioannou M, de la Rosette J, Anastasiadis A Nutrients. 2025; 17(3).

PMID: 39940323 PMC: 11820711. DOI: 10.3390/nu17030465.

The Gut-Kidney Axis in Chronic Kidney Diseases.

Tsuji K, Uchida N, Nakanoh H, Fukushima K, Haraguchi S, Kitamura S Diagnostics (Basel). 2025; 15(1.

PMID: 39795549 PMC: 11719742. DOI: 10.3390/diagnostics15010021.

Inflammatory Bowel Diseases and Nephropathies: Exploring the Gut-Kidney Axis.

De Sire R, La Mantia A, Bonacci L, Testa A, Guarino A, Rispo A Life (Basel). 2025; 14(12.

PMID: 39768250 PMC: 11678131. DOI: 10.3390/life14121541.

The Role of the Gut Microbiome in Urinary Tract Infections: A Narrative Review.

Iqbal Z, Halkjaer S, Ghathian K, Heintz J, Petersen A Nutrients. 2024; 16(21).

PMID: 39519448 PMC: 11547363. DOI: 10.3390/nu16213615.

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