Individuals with Ventromedial Frontal Damage Display Unstable but Transitive Preferences During Decision Making

Overview

Journal Nat Commun

Specialty Biology

Date 2022 Aug 13

PMID 35963856

Authors

Linda Q Yu

Jason Dana

Joseph W Kable

Affiliations

Soon will be listed here.

Abstract

The ventromedial frontal lobe (VMF) is important for decision-making, but the precise causal role of the VMF in the decision process has not been fully established. Previous studies have suggested that individuals with VMF damage violate transitivity, a hallmark axiom of rational decisions. However, these prior studies cannot properly distinguish whether individuals with VMF damage are truly prone to choosing irrationally from whether their preferences are simply more variable. We had individuals with focal VMF damage, individuals with other frontal damage, and healthy controls make repeated choices across three categories-artworks, chocolate bar brands, and gambles. Using proper tests of transitivity, we find that, in our study, individuals with VMF damage make rational decisions consistent with transitive preferences, even though they exhibit greater variability in their preferences. That is, the VMF is necessary for having strong and reliable preferences, but not for being a rational decision maker. VMF damage affects the variability with which value is assessed, but not the consistency with which value is sought.

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References

Bartra O, McGuire J, Kable J . The valuation system: a coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value. Neuroimage. 2013; 76:412-27. PMC: 3756836. DOI: 10.1016/j.neuroimage.2013.02.063. View

Levy D, Glimcher P . The root of all value: a neural common currency for choice. Curr Opin Neurobiol. 2012; 22(6):1027-38. PMC: 4093837. DOI: 10.1016/j.conb.2012.06.001. View

Padoa-Schioppa C, Assad J . Neurons in the orbitofrontal cortex encode economic value. Nature. 2006; 441(7090):223-6. PMC: 2630027. DOI: 10.1038/nature04676. View

Padoa-Schioppa C, Assad J . The representation of economic value in the orbitofrontal cortex is invariant for changes of menu. Nat Neurosci. 2007; 11(1):95-102. PMC: 2646102. DOI: 10.1038/nn2020. View

Studer B, Manes F, Humphreys G, Robbins T, Clark L . Risk-sensitive decision-making in patients with posterior parietal and ventromedial prefrontal cortex injury. Cereb Cortex. 2013; 25(1):1-9. PMC: 4259274. DOI: 10.1093/cercor/bht197. View

Fellows L, Farah M . Dissociable elements of human foresight: a role for the ventromedial frontal lobes in framing the future, but not in discounting future rewards. Neuropsychologia. 2005; 43(8):1214-21. DOI: 10.1016/j.neuropsychologia.2004.07.018. View

Sellitto M, Ciaramelli E, di Pellegrino G . Myopic discounting of future rewards after medial orbitofrontal damage in humans. J Neurosci. 2010; 30(49):16429-36. PMC: 6634874. DOI: 10.1523/JNEUROSCI.2516-10.2010. View

Peters J, DEsposito M . Effects of Medial Orbitofrontal Cortex Lesions on Self-Control in Intertemporal Choice. Curr Biol. 2016; 26(19):2625-2628. DOI: 10.1016/j.cub.2016.07.035. View

Fellows L, Farah M . The role of ventromedial prefrontal cortex in decision making: judgment under uncertainty or judgment per se?. Cereb Cortex. 2007; 17(11):2669-74. DOI: 10.1093/cercor/bhl176. View

10.

Henri-Bhargava A, Simioni A, Fellows L . Ventromedial frontal lobe damage disrupts the accuracy, but not the speed, of value-based preference judgments. Neuropsychologia. 2012; 50(7):1536-42. DOI: 10.1016/j.neuropsychologia.2012.03.006. View

11.

Regenwetter M, Dana J, Davis-Stober C . Transitivity of preferences. Psychol Rev. 2011; 118(1):42-56. DOI: 10.1037/a0021150. View

12.

Regenwetter M, Dana J, Davis-Stober C . Testing transitivity of preferences on two-alternative forced choice data. Front Psychol. 2011; 1:148. PMC: 3153766. DOI: 10.3389/fpsyg.2010.00148. View

13.

Padoa-Schioppa C . Neuronal origins of choice variability in economic decisions. Neuron. 2013; 80(5):1322-36. PMC: 3857585. DOI: 10.1016/j.neuron.2013.09.013. View

14.

Ballesta S, Shi W, Conen K, Padoa-Schioppa C . Values encoded in orbitofrontal cortex are causally related to economic choices. Nature. 2020; 588(7838):450-453. PMC: 7746614. DOI: 10.1038/s41586-020-2880-x. View

15.

Brandstatter E, Gigerenzer G, Hertwig R . The priority heuristic: making choices without trade-offs. Psychol Rev. 2006; 113(2):409-32. PMC: 2891015. DOI: 10.1037/0033-295X.113.2.409. View

16.

Rutledge R, Dean M, Caplin A, Glimcher P . Testing the reward prediction error hypothesis with an axiomatic model. J Neurosci. 2010; 30(40):13525-36. PMC: 2957369. DOI: 10.1523/JNEUROSCI.1747-10.2010. View

17.

Padoa-Schioppa C, Cai X . The orbitofrontal cortex and the computation of subjective value: consolidated concepts and new perspectives. Ann N Y Acad Sci. 2011; 1239:130-7. PMC: 3273987. DOI: 10.1111/j.1749-6632.2011.06262.x. View

18.

Hunt L, Hayden B . A distributed, hierarchical and recurrent framework for reward-based choice. Nat Rev Neurosci. 2017; 18(3):172-182. PMC: 5621622. DOI: 10.1038/nrn.2017.7. View

19.

Vo K, Rutledge R, Chatterjee A, Kable J . Dorsal striatum is necessary for stimulus-value but not action-value learning in humans. Brain. 2014; 137(Pt 12):3129-35. PMC: 4240290. DOI: 10.1093/brain/awu277. View

20.

Bakkour A, Palombo D, Zylberberg A, Kang Y, Reid A, Verfaellie M . The hippocampus supports deliberation during value-based decisions. Elife. 2019; 8. PMC: 6693920. DOI: 10.7554/eLife.46080. View