The Orbitofrontal Cortex and the Computation of Subjective Value: Consolidated Concepts and New Perspectives

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2011 Dec 8

PMID 22145882

Citations 81

Authors

Camillo Padoa-Schioppa

Xinying Cai

Affiliations

Soon will be listed here.

Abstract

Remarkable progress has been made in recent years toward understanding the functions of the orbitofrontal cortex (OFC). The finding that neurons in this area encode the subjective value monkeys assign to different goods while making choices has been confirmed and extended by numerous studies using both primate neurophysiology and human imaging. Moreover, new lesion studies demonstrated that subjective values computed in the OFC are causally and specifically related to choice behavior. Importantly, values in the OFC are attached to goods, not to actions or to spatial locations. Furthermore, subjective values appear to be computed in this area even if the situation does not require a choice. In the light of this growing body of work, we propose that the primary function of the OFC is the computation of good identities and subjective values in an abstract representation. In this view, OFC neurons compute the subjective value of a good whenever that good is behaviorally relevant.

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References

Sumpter C, Temple W, Foster T . The transitivity of choices between different response requirements. J Exp Anal Behav. 2006; 72(2):235-49. PMC: 1284739. DOI: 10.1901/jeab.1999.72-235. View

Baxter M, Gaffan D, Kyriazis D, Mitchell A . Ventrolateral prefrontal cortex is required for performance of a strategy implementation task but not reinforcer devaluation effects in rhesus monkeys. Eur J Neurosci. 2009; 29(10):2049-59. PMC: 2688497. DOI: 10.1111/j.1460-9568.2009.06740.x. View

Kobayashi S, Pinto de Carvalho O, Schultz W . Adaptation of reward sensitivity in orbitofrontal neurons. J Neurosci. 2010; 30(2):534-44. PMC: 2880492. DOI: 10.1523/JNEUROSCI.4009-09.2010. View

Kepecs A, Uchida N, Zariwala H, Mainen Z . Neural correlates, computation and behavioural impact of decision confidence. Nature. 2008; 455(7210):227-31. DOI: 10.1038/nature07200. View

Chaudhry A, Parkinson J, Hinton E, Owen A, Roberts A . Preference judgements involve a network of structures within frontal, cingulate and insula cortices. Eur J Neurosci. 2009; 29(5):1047-55. DOI: 10.1111/j.1460-9568.2009.06646.x. View

Plassmann H, ODoherty J, Rangel A . Appetitive and aversive goal values are encoded in the medial orbitofrontal cortex at the time of decision making. J Neurosci. 2010; 30(32):10799-808. PMC: 6634706. DOI: 10.1523/JNEUROSCI.0788-10.2010. View

Padoa-Schioppa C, Assad J . Neurons in the orbitofrontal cortex encode economic value. Nature. 2006; 441(7090):223-6. PMC: 2630027. DOI: 10.1038/nature04676. View

Fellows L . Advances in understanding ventromedial prefrontal function: the accountant joins the executive. Neurology. 2007; 68(13):991-5. DOI: 10.1212/01.wnl.0000257835.46290.57. View

Simmons J, Minamimoto T, Murray E, Richmond B . Selective ablations reveal that orbital and lateral prefrontal cortex play different roles in estimating predicted reward value. J Neurosci. 2010; 30(47):15878-87. PMC: 3021956. DOI: 10.1523/JNEUROSCI.1802-10.2010. View

10.

Gottfried J, ODoherty J, Dolan R . Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science. 2003; 301(5636):1104-7. DOI: 10.1126/science.1087919. View

11.

Padoa-Schioppa C . Range-adapting representation of economic value in the orbitofrontal cortex. J Neurosci. 2009; 29(44):14004-14. PMC: 2776749. DOI: 10.1523/JNEUROSCI.3751-09.2009. View

12.

Shenhav A, Greene J . Moral judgments recruit domain-general valuation mechanisms to integrate representations of probability and magnitude. Neuron. 2010; 67(4):667-77. DOI: 10.1016/j.neuron.2010.07.020. View

13.

Hare T, ODoherty J, Camerer C, Schultz W, Rangel A . Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors. J Neurosci. 2008; 28(22):5623-30. PMC: 6670807. DOI: 10.1523/JNEUROSCI.1309-08.2008. View

14.

Baxter M, Gaffan D, Kyriazis D, Mitchell A . Dorsolateral prefrontal lesions do not impair tests of scene learning and decision-making that require frontal-temporal interaction. Eur J Neurosci. 2008; 28(3):491-9. PMC: 2522287. DOI: 10.1111/j.1460-9568.2008.06353.x. View

15.

Price J . Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regions. Ann N Y Acad Sci. 2007; 1121:54-71. DOI: 10.1196/annals.1401.008. View

16.

Gallagher M, McMahan R, Schoenbaum G . Orbitofrontal cortex and representation of incentive value in associative learning. J Neurosci. 1999; 19(15):6610-4. PMC: 6782791. View

17.

Plassmann H, ODoherty J, Rangel A . Orbitofrontal cortex encodes willingness to pay in everyday economic transactions. J Neurosci. 2007; 27(37):9984-8. PMC: 6672655. DOI: 10.1523/JNEUROSCI.2131-07.2007. View

18.

Hosokawa T, Kato K, Inoue M, Mikami A . Neurons in the macaque orbitofrontal cortex code relative preference of both rewarding and aversive outcomes. Neurosci Res. 2007; 57(3):434-45. DOI: 10.1016/j.neures.2006.12.003. View

19.

Levy I, Snell J, Nelson A, Rustichini A, Glimcher P . Neural representation of subjective value under risk and ambiguity. J Neurophysiol. 2009; 103(2):1036-47. DOI: 10.1152/jn.00853.2009. View

20.

Critchley H . Neural mechanisms of autonomic, affective, and cognitive integration. J Comp Neurol. 2005; 493(1):154-66. DOI: 10.1002/cne.20749. View