» Articles » PMID: 35959460

Protein Kinase A in Cellular Migration-Niche Signaling of a Ubiquitous Kinase

Overview
Specialty Biology
Date 2022 Aug 12
PMID 35959460
Authors
Affiliations
Soon will be listed here.
Abstract

Cell migration requires establishment and maintenance of directional polarity, which in turn requires spatial heterogeneity in the regulation of protrusion, retraction, and adhesion. Thus, the signaling proteins that regulate these various structural processes must also be distinctly regulated in subcellular space. Protein Kinase A (PKA) is a ubiquitous serine/threonine kinase involved in innumerable cellular processes. In the context of cell migration, it has a paradoxical role in that global inhibition or activation of PKA inhibits migration. It follows, then, that the subcellular regulation of PKA is key to bringing its proper permissive and restrictive functions to the correct parts of the cell. Proper subcellular regulation of PKA controls not only when and where it is active but also specifies the targets for that activity, allowing the cell to use a single, promiscuous kinase to exert distinct functions within different subcellular niches to facilitate cell movement. In this way, understanding PKA signaling in migration is a study in context and in the elegant coordination of distinct functions of a single protein in a complex cellular process.

Citing Articles

Chemokines Signature and T Cell Dynamics in Leishmaniasis: Molecular insight and therapeutic application.

Upadhyay S, Kumar S, Singh V, Tiwari R, Kumar A, Sundar S Expert Rev Mol Med. 2024; 1-55.

PMID: 39587036 PMC: 11707835. DOI: 10.1017/erm.2024.36.


The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein.

Kang M, Otani Y, Guo Y, Yan J, Goult B, Howe A Proc Natl Acad Sci U S A. 2024; 121(13):e2314947121.

PMID: 38513099 PMC: 10990152. DOI: 10.1073/pnas.2314947121.


Evaluating Prophylactic Effect of Bovine Colostrum on Intestinal Barrier Function in Zonulin Transgenic Mice: A Transcriptomic Study.

Asbjornsdottir B, Sigurdsson S, Miranda-Ribera A, Fiorentino M, Konno T, Lan J Int J Mol Sci. 2023; 24(19).

PMID: 37834178 PMC: 10572565. DOI: 10.3390/ijms241914730.

References
1.
Comer S, Nagy Z, Bolado A, von Kriegsheim A, Gambaryan S, Walter U . The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets. J Thromb Haemost. 2020; 18(11):3002-3012. DOI: 10.1111/jth.15028. View

2.
Taylor S, Kim C, Vigil D, Haste N, Yang J, Wu J . Dynamics of signaling by PKA. Biochim Biophys Acta. 2005; 1754(1-2):25-37. DOI: 10.1016/j.bbapap.2005.08.024. View

3.
Howe A . Regulation of actin-based cell migration by cAMP/PKA. Biochim Biophys Acta. 2004; 1692(2-3):159-74. DOI: 10.1016/j.bbamcr.2004.03.005. View

4.
Yu H, Yuan C, Westenbroek R, Catterall W . The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac Ca1.2 calcium channels. J Gen Physiol. 2018; 150(6):883-889. PMC: 5987873. DOI: 10.1085/jgp.201711818. View

5.
Petrie R, Doyle A, Yamada K . Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol. 2009; 10(8):538-49. PMC: 2752299. DOI: 10.1038/nrm2729. View