A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer

Overview

Journal Front Physiol

Date 2019 Jul 6

PMID 31275168

Citations 46

Authors

Jimena Canales

Diego Morales

Constanza Blanco

Jose Rivas

Nicolas Diaz

Ioannis Angelopoulos

Oscar Cerda

Affiliations

Soon will be listed here.

Abstract

Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from the primary tumor to distant organs. At the molecular level, migration is the result of several coordinated events involving mechanical forces and cellular signaling, where the second messenger Ca plays a pivotal role. Therefore, elucidating the regulation of intracellular Ca levels is key for a complete understanding of the mechanisms controlling cellular migration. In this regard, understanding the function of Transient Receptor Potential (TRP) channels, which are fundamental determinants of Ca signaling, is critical to uncovering mechanisms of mechanotransduction during cell migration and, consequently, in pathologies closely linked to it, such as cancer. Here, we review recent studies on the association between TRP channels and migration-related mechanotransduction events, as well as in the involvement of TRP channels in the migration-dependent pathophysiological process of metastasis.

Citing Articles

TRPC3-mediated NFATc1 calcium signaling promotes triple negative breast cancer migration through regulating glypican-6 and focal adhesion.

Wang Y, Zhuang X, Qi Y, Yiu L, Li Z, Chan Y Pflugers Arch. 2024; 477(2):253-272.

PMID: 39436410 PMC: 11762004. DOI: 10.1007/s00424-024-03030-y.

Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets.

Hegde S, Akbar H, Wellendorf A, Nestheide S, Johnson J, Zhao X Blood. 2024; 144(16):1732-1746.

PMID: 39088777 PMC: 11830982. DOI: 10.1182/blood.2023021453.

The biophysics of cell motility through mechanochemically challenging environments.

Caruso A, Logue J Curr Opin Cell Biol. 2024; 90:102404.

PMID: 39053178 PMC: 11392632. DOI: 10.1016/j.ceb.2024.102404.

A panel based on three-miRNAs as diagnostic biomarker for prostate cancer.

Chen S, Lu C, Lin S, Sun C, Wen Z, Ge Z Front Genet. 2024; 15:1371441.

PMID: 38818039 PMC: 11137311. DOI: 10.3389/fgene.2024.1371441.

Roles of TRPM channels in glioma.

Chen Z, Xie H, Liu J, Zhao J, Huang R, Xiang Y Cancer Biol Ther. 2024; 25(1):2338955.

PMID: 38680092 PMC: 11062369. DOI: 10.1080/15384047.2024.2338955.

References

Wilson P, Geng L, Li X, Burrow C . The PKD1 gene product, "polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia. Lab Invest. 1999; 79(10):1311-23. View

Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M . Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem. 2000; 275(48):37559-64. DOI: 10.1074/jbc.M006635200. View

Geng L, Burrow C, Li H, Wilson P . Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation. Biochim Biophys Acta. 2000; 1535(1):21-35. DOI: 10.1016/s0925-4439(00)00079-x. View

Laukaitis C, Webb D, Donais K, Horwitz A . Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells. J Cell Biol. 2001; 153(7):1427-40. PMC: 2150721. DOI: 10.1083/jcb.153.7.1427. View

Locascio A, Nieto M . Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration. Curr Opin Genet Dev. 2001; 11(4):464-9. DOI: 10.1016/s0959-437x(00)00218-5. View

Glading A, Lauffenburger D, Wells A . Cutting to the chase: calpain proteases in cell motility. Trends Cell Biol. 2002; 12(1):46-54. DOI: 10.1016/s0962-8924(01)02179-1. View

Small J, Stradal T, Vignal E, Rottner K . The lamellipodium: where motility begins. Trends Cell Biol. 2002; 12(3):112-20. DOI: 10.1016/s0962-8924(01)02237-1. View

Wehrle-Haller B, Imhof B . The inner lives of focal adhesions. Trends Cell Biol. 2002; 12(8):382-9. DOI: 10.1016/s0962-8924(02)02321-8. View

Friedl P, Wolf K . Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer. 2003; 3(5):362-74. DOI: 10.1038/nrc1075. View

10.

Cioffi D, Wu S, Stevens T . On the endothelial cell I(SOC). Cell Calcium. 2003; 33(5-6):323-36. DOI: 10.1016/s0143-4160(03)00046-0. View

11.

Greka A, Navarro B, Oancea E, Duggan A, Clapham D . TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci. 2003; 6(8):837-45. DOI: 10.1038/nn1092. View

12.

Price L, Langeslag M, Ten Klooster J, Hordijk P, Jalink K, Collard J . Calcium signaling regulates translocation and activation of Rac. J Biol Chem. 2003; 278(41):39413-21. DOI: 10.1074/jbc.M302083200. View

13.

Hahn K, DeBiasio R, Taylor D . Patterns of elevated free calcium and calmodulin activation in living cells. Nature. 1992; 359(6397):736-8. DOI: 10.1038/359736a0. View

14.

Suzuki M, Hirao A, Mizuno A . Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem. 2003; 278(51):51448-53. DOI: 10.1074/jbc.M308212200. View

15.

Zaidel-Bar R, Ballestrem C, Kam Z, Geiger B . Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J Cell Sci. 2003; 116(Pt 22):4605-13. DOI: 10.1242/jcs.00792. View

16.

Clapham D . TRP channels as cellular sensors. Nature. 2003; 426(6966):517-24. DOI: 10.1038/nature02196. View

17.

Ridley A, Schwartz M, Burridge K, Firtel R, Ginsberg M, Borisy G . Cell migration: integrating signals from front to back. Science. 2003; 302(5651):1704-9. DOI: 10.1126/science.1092053. View

18.

Giannone G, Ronde P, Gaire M, Beaudouin J, Haiech J, Ellenberg J . Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions. J Biol Chem. 2004; 279(27):28715-23. DOI: 10.1074/jbc.M404054200. View

19.

Bezzerides V, Ramsey I, Kotecha S, Greka A, Clapham D . Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004; 6(8):709-20. DOI: 10.1038/ncb1150. View

20.

Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet J . TRPM4 regulates calcium oscillations after T cell activation. Science. 2004; 306(5700):1374-7. DOI: 10.1126/science.1098845. View