Focal Adhesion Kinase: in Command and Control of Cell Motility

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2005 Feb 3

PMID 15688067

Citations 1177

Authors

Satyajit K Mitra

Daniel A Hanson

David D Schlaepfer

Affiliations

Soon will be listed here.

Abstract

A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.

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