Long Noncoding RNA (lncRNA) HOTAIR: Pathogenic Roles and Therapeutic Opportunities in Gastric Cancer

Overview

Journal Genes Dis

Date 2022 Jul 25

PMID 35873034

Authors

Wencheng Kong

Guang Yin

Sixin Zheng

Xinchun Liu

Akao Zhu

Panpan Yu

Jian Zhang

Yuqiang Shan

Rongchao Ying

Huicheng Jin

Affiliations

Soon will be listed here.

Abstract

Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease. Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer. HOTAIR is an effective epigenetic agent known as long noncoding RNA (lncRNA). HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors, leading to genomic stability, proliferation, survival, invasion, migration, metastasis, and drug resistance. In the present article, we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer, whereas elucidation of HOTAIR-protein and HOTAIR-DNA interactions can be helpful in the identification of cancer processes, leading to the development of potential therapeutic strategies.

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