The Analysis of LncRNA HOTAIR Rs12826786 C>T Polymorphism and Gastric Cancer Susceptibility in a Turkish Population: Lack of Any Association in a Hospital-based Case-control Study

Overview

Journal Ir J Med Sci

Specialty General Medicine

Date 2017 Mar 26

PMID 28342055

Citations 11

Authors

Y Ulger

E Dadas

B Yalinbas Kaya

A T Sumbul

A Genc

S Bayram

Affiliations

Soon will be listed here.

Abstract

Background: The HOX transcript antisense intergenic RNA (HOTAIR), a well-known long noncoding RNA (lncRNA), has been widely identified to participate in pathogenesis of multiple cancers. An aberrant up-regulation and biological functions have been observed in gastric cancer (GC). A common single nucleotide polymorphism (SNP) (rs12826786 C>T) at the HOTAIR has been reported to influence HOTAIR expression, but its association with GC has yet to be investigated in Turkish population.

Aim: The aim of the present study was to investigate whether HOTAIR rs12826786 C>T polymorphism could be involved in the risk of GC susceptibility in Turkish population.

Methods: We genotyped HOTAIR rs12826786 C>T polymorphism in 312 Turkish individuals including 105 GC patients and 207 healthy controls matched on age and gender by a Real-Time Polymerase Chain Reaction (PCR) with the TaqMan assay.

Results: No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs12826786 C>T polymorphism among GC and healthy control subjects (P > 0.05).

Conclusions: Our results demonstrate that the HOTAIR rs12826786 C>T polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. Independent studies are needed to validate our findings in a larger series, as well as in patients of different ethnic origins.

Citing Articles

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Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case-Control Study.

Yalinbas Kaya B, Peker B, Tugrul F, Alkan Tali O, Bayram S Turk J Gastroenterol. 2022; 33(8):689-695.

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Kong W, Yin G, Zheng S, Liu X, Zhu A, Yu P Genes Dis. 2022; 9(5):1269-1280.

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Dysregulation of lncRNA in -Infected Gastric Cancer Cells.

Yousefi L, Owaysee Osquee H, Ghotaslou R, Rezaee M, Pirzadeh T, Sadeghi J Biomed Res Int. 2021; 2021:6911734.

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Contributions of HOTAIR polymorphisms to the susceptibility of cancer.

Li H, Deng N, Zhao X, Liu J, He T, Ding X Int J Clin Oncol. 2021; 26(6):1022-1038.

PMID: 33634340 DOI: 10.1007/s10147-021-01884-1.

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