Emerging Role of LncRNAs in Osteoarthritis: An Updated Review

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Oct 28

PMID 36304464

Authors

Rongliang Wang

Hoi Ting Shiu

Wayne Yuk Wai Lee

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is a prevalent joint disease, which is associated with progressive articular cartilage loss, synovial inflammation, subchondral sclerosis and meniscus injury. The molecular mechanism underlying OA pathogenesis is multifactorial. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs with length more than 200 nucleotides. They have various functions such as modulating transcription and protein activity, as well as forming endogenous small interfering RNAs (siRNAs) and microRNA (miRNA) sponges. Emerging evidence suggests that lncRNAs might be involved in the pathogenesis of OA which opens up a new avenue for the development of new biomarkers and therapeutic strategies. The purpose of this review is to summarize the current clinical and basic experiments related to lncRNAs and OA with a focus on the extensively studied H19, GAS5, MALAT1, XIST and HOTAIR. The potential translational value of these lncRNAs as therapeutic targets for OA is also discussed.

Citing Articles

Bioactive Compounds and Their Chondroprotective Effects for Osteoarthritis Amelioration: A Focus on Nanotherapeutic Strategies, Epigenetic Modifications, and Gut Microbiota.

Hridayanka K, Duttaroy A, Basak S Nutrients. 2024; 16(21).

PMID: 39519419 PMC: 11547880. DOI: 10.3390/nu16213587.

Targeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in Osteoarthritis.

Wang R, Mehrjou B, Dehghan-Banian D, Wang B, Li Q, Deng S Arthritis Rheumatol. 2024; 77(3):283-297.

PMID: 39482250 PMC: 11865692. DOI: 10.1002/art.43028.

Serum lncRNA ITGB2-AS1 and ICAM-1 as novel biomarkers for rheumatoid arthritis and osteoarthritis diagnosis.

Selim A, Elsabagh Y, El-Sawalhi M, Ismail N, Senousy M BMC Med Genomics. 2024; 17(1):247.

PMID: 39379962 PMC: 11462822. DOI: 10.1186/s12920-024-01993-6.

Exosomes-Shuttled lncRNA SNHG7 by Bone Marrow Mesenchymal Stem Cells Alleviates Osteoarthritis Through Targeting miR-485-5p/FSP1 Axis-Mediated Chondrocytes Ferroptosis and Inflammation.

Wang Y, Hu K, Liao C, Han T, Jiang F, Gao Z Tissue Eng Regen Med. 2024; 21(8):1203-1216.

PMID: 39363054 PMC: 11589043. DOI: 10.1007/s13770-024-00668-8.

LncRNA-mediated cartilage homeostasis in osteoarthritis: a narrative review.

Zhang L, Zhang H, Xie Q, Feng H, Li H, Li Z Front Med (Lausanne). 2024; 11:1326843.

PMID: 38449881 PMC: 10915071. DOI: 10.3389/fmed.2024.1326843.

References

Shermane Lim Y, Xiang X, Garg M, Le M, Wong A, Wang L . The double-edged sword of H19 lncRNA: Insights into cancer therapy. Cancer Lett. 2020; 500:253-262. DOI: 10.1016/j.canlet.2020.11.006. View

Wu X, Yin S, Yan L, Liu Y, Shang L, Liu J . lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p. J Immunol Res. 2022; 2022:1816217. PMC: 9132666. DOI: 10.1155/2022/1816217. View

Gutschner T, Baas M, Diederichs S . Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases. Genome Res. 2011; 21(11):1944-54. PMC: 3205578. DOI: 10.1101/gr.122358.111. View

Xu Y, Duan L, Liu S, Yang Y, Qiao Z, Shi L . Long intergenic non-protein coding RNA 00707 regulates chondrocyte apoptosis and proliferation in osteoarthritis by serving as a sponge for microRNA-199-3p. Bioengineered. 2022; 13(4):11137-11145. PMC: 9208525. DOI: 10.1080/21655979.2022.2061287. View

Budd E, Nalesso G, Mobasheri A . Extracellular genomic biomarkers of osteoarthritis. Expert Rev Mol Diagn. 2017; 18(1):55-74. DOI: 10.1080/14737159.2018.1415757. View

Chen K, Fang H, Xu N . LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis. Life Sci. 2020; 258:118095. DOI: 10.1016/j.lfs.2020.118095. View

Wang Y, Yao-Li , Liang S, Ding L, Feng-Li , Guan J . LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF-β/SMAD4 signaling. J Bone Miner Metab. 2021; 39(4):534-546. DOI: 10.1007/s00774-020-01199-7. View

Zhou C, He T, Chen L . LncRNA CASC19 accelerates chondrocytes apoptosis and proinflammatory cytokine production to exacerbate osteoarthritis development through regulating the miR-152-3p/DDX6 axis. J Orthop Surg Res. 2021; 16(1):399. PMC: 8218455. DOI: 10.1186/s13018-021-02543-x. View

Jiang H, Pang H, Wu P, Cao Z, Li Z, Yang X . LncRNA SNHG5 promotes chondrocyte proliferation and inhibits apoptosis in osteoarthritis by regulating miR-10a-5p/H3F3B axis. Connect Tissue Res. 2020; 62(6):605-614. DOI: 10.1080/03008207.2020.1825701. View

10.

Chen S, Fu P, Wu H, Pei M . Meniscus, articular cartilage and nucleus pulposus: a comparative review of cartilage-like tissues in anatomy, development and function. Cell Tissue Res. 2017; 370(1):53-70. PMC: 5645221. DOI: 10.1007/s00441-017-2613-0. View

11.

Li L, Lv G, Wang B, Kuang L . The role of lncRNA XIST/miR-211 axis in modulating the proliferation and apoptosis of osteoarthritis chondrocytes through CXCR4 and MAPK signaling. Biochem Biophys Res Commun. 2018; 503(4):2555-2562. DOI: 10.1016/j.bbrc.2018.07.015. View

12.

Zhu J, He T, Wei Z, Wang Y . LncRNA FAS-AS1 promotes the degradation of extracellular matrix of cartilage in osteoarthritis. Eur Rev Med Pharmacol Sci. 2018; 22(10):2966-2972. DOI: 10.26355/eurrev_201805_15051. View

13.

Madry H . Surgical therapy in osteoarthritis. Osteoarthritis Cartilage. 2022; 30(8):1019-1034. DOI: 10.1016/j.joca.2022.01.012. View

14.

Jiang Z, Du X, Wen X, Li H, Zeng A, Sun H . Whole-Transcriptome Sequence of Degenerative Meniscus Cells Unveiling Diagnostic Markers and Therapeutic Targets for Osteoarthritis. Front Genet. 2021; 12:754421. PMC: 8554121. DOI: 10.3389/fgene.2021.754421. View

15.

Wang T, Liu Y, Wang Y, Huang X, Zhao W, Zhao Z . Long non-coding RNA XIST promotes extracellular matrix degradation by functioning as a competing endogenous RNA of miR-1277-5p in osteoarthritis. Int J Mol Med. 2019; 44(2):630-642. PMC: 6605283. DOI: 10.3892/ijmm.2019.4240. View

16.

Kang Y, Song J, Kim D, Ahn C, Park S, Chun C . PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770. J Orthop Res. 2015; 34(3):412-8. DOI: 10.1002/jor.23046. View

17.

Lu C, Li Z, Hu S, Cai Y, Peng K . LncRNA PART-1 targets TGFBR2/Smad3 to regulate cell viability and apoptosis of chondrocytes via acting as miR-590-3p sponge in osteoarthritis. J Cell Mol Med. 2019; 23(12):8196-8205. PMC: 6850963. DOI: 10.1111/jcmm.14690. View

18.

Liu Y, Liu K, Tang C, Shi Z, Jing K, Zheng J . Long non-coding RNA XIST contributes to osteoarthritis progression via miR-149-5p/DNMT3A axis. Biomed Pharmacother. 2020; 128:110349. DOI: 10.1016/j.biopha.2020.110349. View

19.

Li H, Xie S, Li H, Zhang R, Zhang H . LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis. Life Sci. 2019; 254:116801. DOI: 10.1016/j.lfs.2019.116801. View

20.

Muller-Tidow C, Diederichs S, Thomas M, Serve H . Genome-wide screening for prognosis-predicting genes in early-stage non-small-cell lung cancer. Lung Cancer. 2004; 45 Suppl 2:S145-50. DOI: 10.1016/j.lungcan.2004.07.979. View