Dynamic Transcriptomic MA Decoration: Writers, Erasers, Readers and Functions in RNA Metabolism

Overview

Journal Cell Res

Specialty Cell Biology

Date 2018 May 24

PMID 29789545

Citations 807

Authors

Ying Yang

Phillip J Hsu

Yu-Sheng Chen

Yun-Gui Yang

Affiliations

Soon will be listed here.

Abstract

N-methyladenosine (mA) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove mA have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the mA modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

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