Long Noncoding RNAs in Cancer: from Function to Translation

Overview

Journal Trends Cancer

Publisher Cell Press

Specialty Oncology

Date 2015 Dec 23

PMID 26693181

Citations 141

Authors

Anirban Sahu

Udit Singhal

Arul M Chinnaiyan

Affiliations

Soon will be listed here.

Abstract

While our understanding of the molecular mechanisms underlying cancer has significantly improved, most of our knowledge focuses on protein-coding genes that make up a fraction of the genome. Recent studies have uncovered thousands of long noncoding RNAs (lncRNAs) that populate the cancer genome. A subset of these molecules shows striking cancer- and lineage-specific expression patterns, suggesting they may be potential drivers of cancer biology and have utility as clinical biomarkers. Here, we discuss emerging modalities of lncRNA biology and their interplay with cancer-associated concepts, including epigenetic regulation, DNA damage and cell cycle control, microRNA silencing, signal transduction pathways, and hormone-driven disease. Additionally, we highlight the translational impact of lncRNAs, tools for their mechanistic investigation, and directions for future lncRNA research.

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