Break on Through: The Role of Innate Immunity and Barrier Defence in Atopic Dermatitis and Psoriasis

Overview

Journal Skin Health Dis

Publisher Oxford University Press

Specialty Dermatology

Date 2022 Jun 9

PMID 35677926

Authors

H C Hawerkamp

C M R Fahy

P G Fallon

C Schwartz

Affiliations

Soon will be listed here.

Abstract

The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances made in the field of the skin innate immune system and its interaction with adaptive immunity. We review gene variants associated with atopic dermatitis and psoriasis that affect innate immune mechanisms and skin barrier integrity. Finally, we discuss how current and future therapies may affect innate immune responses and skin barrier integrity in a generalized or more targeted approach in order to ameliorate disease in patients.

Citing Articles

The Roles of Innate Immune Cells in Atopic Dermatitis.

Pan Y, Wang Y, Xu M, Zhong M, Peng X, Zeng K J Innate Immun. 2024; 16(1):385-396.

PMID: 39025048 PMC: 11324229. DOI: 10.1159/000539534.

Allergic Contact Cell-Mediated Hypersensitivity in Psoriasis: A Narrative Minireview.

Stanescu A, Cristea A, Bejan G, Vieru M, Simionescu A, Popescu F Medicina (Kaunas). 2022; 58(7).

PMID: 35888633 PMC: 9324524. DOI: 10.3390/medicina58070914.

Obesity-Mediated Immune Modulation: One Step Forward, (Th)2 Steps Back.

Schmidt V, Hogan A, Fallon P, Schwartz C Front Immunol. 2022; 13:932893.

PMID: 35844529 PMC: 9279727. DOI: 10.3389/fimmu.2022.932893.

Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis.

Hawerkamp H, Fahy C, Fallon P, Schwartz C Skin Health Dis. 2022; 2(2):e99.

PMID: 35677926 PMC: 9168024. DOI: 10.1002/ski2.99.

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