Interleukin-17A and Keratinocytes in Psoriasis

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Feb 20

PMID 32070069

Citations 105

Authors

Masutaka Furue

Kazuhisa Furue

Gaku Tsuji

Takeshi Nakahara

Affiliations

Soon will be listed here.

Abstract

The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates a crucial pathogenic role of IL-17A in this autoinflammatory skin disease. IL-17A accelerates the proliferation of epidermal keratinocytes. Keratinocytes produce a myriad of antimicrobial peptides and chemokines, such as CXCL1, CXCL2, CXCL8, and CCL20. Antimicrobial peptides enhance skin inflammation. IL-17A is capable of upregulating the production of these chemokines and antimicrobial peptides in keratinocytes. CXCL1, CXCL2, and CXCL8 recruit neutrophils and CCL20 chemoattracts IL-17A-producing CCR6 immune cells, which further contributes to forming an IL-17A-rich milieu. This feed-forward pathogenic process results in characteristic histopathological features, such as epidermal hyperproliferation, intraepidermal neutrophilic microabscess, and dermal CCR6 cell infiltration. In this review, we focus on IL-17A and keratinocyte interaction regarding psoriasis pathogenesis.

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References

Sun D, Yeh C, So E, Wang L, Wei T, Chang M . Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression. Cytokine. 2013; 62(3):360-8. DOI: 10.1016/j.cyto.2013.03.017. View

Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M . Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. J Invest Dermatol. 2010; 131(1):108-17. DOI: 10.1038/jid.2010.255. View

Conti H, Gaffen S . IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans. J Immunol. 2015; 195(3):780-8. PMC: 4507294. DOI: 10.4049/jimmunol.1500909. View

Kulke R, Todt-Pingel I, Rademacher D, Rowert J, Schroder J, Christophers E . Co-localized overexpression of GRO-alpha and IL-8 mRNA is restricted to the suprapapillary layers of psoriatic lesions. J Invest Dermatol. 1996; 106(3):526-30. DOI: 10.1111/1523-1747.ep12343916. View

Kolbinger F, Loesche C, Valentin M, Jiang X, Cheng Y, Jarvis P . β-Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis. J Allergy Clin Immunol. 2016; 139(3):923-932.e8. DOI: 10.1016/j.jaci.2016.06.038. View

Takahashi T, Kulkarni N, Lee E, Zhang L, Wong G, Gallo R . Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors. Sci Rep. 2018; 8(1):4032. PMC: 5838106. DOI: 10.1038/s41598-018-22409-3. View

Masaki S, Bayaraa B, Imafuku S . Prevalence of inflammatory bowel disease in Japanese psoriatic patients. J Dermatol. 2019; 46(7):590-594. DOI: 10.1111/1346-8138.14900. View

Shi X, Jin L, Dang E, Chang T, Feng Z, Liu Y . IL-17A upregulates keratin 17 expression in keratinocytes through STAT1- and STAT3-dependent mechanisms. J Invest Dermatol. 2011; 131(12):2401-8. DOI: 10.1038/jid.2011.222. View

Yamamoto T, Kawada A . Clinical characteristics of Japanese patients with psoriatic arthritis: Comparison with East Asian countries. J Dermatol. 2017; 45(3):273-278. DOI: 10.1111/1346-8138.14097. View

10.

Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang Y, Homey B . Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007; 449(7162):564-9. DOI: 10.1038/nature06116. View

11.

Tokuyama M, Shimizu T, Yamada T, Kondoh A, Mabuchi T . Case of psoriasis vulgaris with atrial fibrillation, heart failure and chronic kidney disease which were found accidentally through blood examination during apremilast treatment. J Dermatol. 2019; 46(7):e239-e240. DOI: 10.1111/1346-8138.14784. View

12.

Conti H, Shen F, Nayyar N, Stocum E, Sun J, Lindemann M . Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med. 2009; 206(2):299-311. PMC: 2646568. DOI: 10.1084/jem.20081463. View

13.

Yamamoto T, Ohtsuki M, Sano S, Morita A, Igarashi A, Okuyama R . Switching biologics in the treatment of psoriatic arthritis in Japan. J Dermatol. 2018; 46(3):e113-e114. DOI: 10.1111/1346-8138.14622. View

14.

Kamata M, Tada Y . Safety of biologics in psoriasis. J Dermatol. 2017; 45(3):279-286. DOI: 10.1111/1346-8138.14096. View

15.

Korman N . Management of psoriasis as a systemic disease: what is the evidence?. Br J Dermatol. 2019; 182(4):840-848. PMC: 7187293. DOI: 10.1111/bjd.18245. View

16.

Miller R . The Koebner phenomenon. Int J Dermatol. 1982; 21(4):192-7. DOI: 10.1111/j.1365-4362.1982.tb02070.x. View

17.

Kamiya K, Karakawa M, Komine M, Kishimoto M, Sugai J, Ohtsuki M . Results of a retrospective study on the efficacy and safety of adalimumab 80 mg administrated every other week in patients with psoriasis at a single Japanese institution. J Dermatol. 2019; 46(3):199-205. DOI: 10.1111/1346-8138.14782. View

18.

Johnston A, Xing X, Wolterink L, Barnes D, Yin Z, Reingold L . IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. J Allergy Clin Immunol. 2017; 140(1):109-120. PMC: 5494022. DOI: 10.1016/j.jaci.2016.08.056. View

19.

Mease P, Smolen J, Behrens F, Nash P, Liu Leage S, Li L . A head-to-head comparison of the efficacy and safety of ixekizumab and adalimumab in biological-naïve patients with active psoriatic arthritis: 24-week results of a randomised, open-label, blinded-assessor trial. Ann Rheum Dis. 2019; 79(1):123-131. PMC: 6937408. DOI: 10.1136/annrheumdis-2019-215386. View

20.

Mabuchi T, Takekoshi T, Hwang S . Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis. J Immunol. 2011; 187(10):5026-31. DOI: 10.4049/jimmunol.1101817. View