Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2017 Aug 26

PMID 28839348

Citations 5

Authors

Yalin Hu

Junling Wang

Huiyun Zhang

Hua Xie

Weiwei Song

Qijun Jiang

Nan Zhao

Shaoheng He

Affiliations

Soon will be listed here.

Abstract

IL-18 has been found to be associated with eczema. However, little is known of the role of IL-18 binding protein (BP) and IL-18 receptor (R) in eczema. We therefore investigated the expression of IL-18, IL-18BP, and IL-18R on mast cells by using flow cytometry analysis and mouse eczema model. The results showed that plasma free IL-18 and free IL-18BP levels in eczema patients were higher than those in healthy controls. IL-18 provoked up to 3.1-fold increase in skin mast cells. IL-18 induced also an increase in IL-18BP+ mast cells, but a reduction of IL-18R+ mast cells in mouse eczema skin. It was found that house dust mite allergen Der p1 and egg allergen OVA induced upregulation of the expression of IL-18, IL-18BP, and IL-18R mRNAs in HMC-1 cells following 2 and 16 h incubation. In conclusion, correlation of IL-18 and IL-18BP in eczema plasma suggests an important balance between IL-18 and IL-18BP in eczema. The decrease in molar concentration ratio of plasma IL-18BP/IL-18 and allergen-induced upregulated expression of IL-18 and IL-18R in skin mast cells of the patients with eczema suggests that anti-IL-18 including IL-18BP therapy may be useful for the treatment of eczema.

Citing Articles

Interleukin‑18 binding protein: Biological properties and roles in human and animal immune regulation (Review).

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Allergens induce upregulated IL-18 and IL-18Rα expression in blood Th2 and Th17 cells of patients with allergic asthma.

Wang J, Zhan M, Zhai Y, Wang S, Gu F, Zhao Z Clin Exp Immunol. 2024; 217(1):31-44.

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Interleukin-18 and IL-18BP in inflammatory dermatological diseases.

Wang X, Wang L, Wen X, Zhang L, Jiang X, He G Front Immunol. 2023; 14:955369.

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