MiRNA-guided Reprogramming of Glucose and Glutamine Metabolism and Its Impact on Cell Adhesion/migration During Solid Tumor Progression

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2022 Mar 29

PMID 35348905

Authors

Lorena Quirico

Francesca Orso

Stefania Cucinelli

Mladen Paradzik

Dora Natalini

Giorgia Centonze

Alberto Dalmasso

Sofia La Vecchia

Martina Coco

Valentina Audrito

Chiara Riganti

Paola Defilippi

Daniela Taverna

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs about 22 nucleotides in length that regulate the expression of target genes post-transcriptionally, and are highly involved in cancer progression. They are able to impact a variety of cell processes such as proliferation, apoptosis and differentiation and can consequently control tumor initiation, tumor progression and metastasis formation. miRNAs can regulate, at the same time, metabolic gene expression which, in turn, influences relevant traits of malignancy such as cell adhesion, migration and invasion. Since the interaction between metabolism and adhesion or cell movement has not, to date, been well understood, in this review, we will specifically focus on miRNA alterations that can interfere with some metabolic processes leading to the modulation of cancer cell movement. In addition, we will analyze the signaling pathways connecting metabolism and adhesion/migration, alterations that often affect cancer cell dissemination and metastasis formation.

Citing Articles

Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review).

Bin Wan Mohd Nor W, Kwong S, Fuzi A, Said N, Jamil A, Lee Y Int J Mol Med. 2025; 55(3).

PMID: 39820715 PMC: 11759585. DOI: 10.3892/ijmm.2025.5487.

miR-450b-5p promotes development of endometriosis by inhibiting the GABPA/HOXD10 axis.

Huang Y, Wang Y, Li R, Liu Y, Yang Y iScience. 2025; 27(12):111487.

PMID: 39759007 PMC: 11696641. DOI: 10.1016/j.isci.2024.111487.

miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthma.

Sharma R, Mendez K, Begum S, Chu S, Prince N, Hecker J EBioMedicine. 2024; 112:105534.

PMID: 39740296 PMC: 11750448. DOI: 10.1016/j.ebiom.2024.105534.

Editorial: Altered metabolic traits in gastrointestinal tract cancers.

Parte S, Pothuraju R, Kumavath R, Bhatia R, Nimmakayala R, Gautam S Front Endocrinol (Lausanne). 2024; 15:1390877.

PMID: 38841308 PMC: 11150827. DOI: 10.3389/fendo.2024.1390877.

The Association of miRNA10a and Glucose Transporters in Oral Squamous Cell Carcinoma With Diabetes: A Pilot Study.

R S, R Jr P, Jayaraman S, Palati S Cureus. 2024; 16(1):e51752.

PMID: 38318595 PMC: 10841624. DOI: 10.7759/cureus.51752.

References

Annese T, Tamma R, De Giorgis M, Ribatti D . microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis. Front Oncol. 2020; 10:581007. PMC: 7729128. DOI: 10.3389/fonc.2020.581007. View

Friedman R, Farh K, Burge C, Bartel D . Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2008; 19(1):92-105. PMC: 2612969. DOI: 10.1101/gr.082701.108. View

Calin G, Dumitru C, Shimizu M, Bichi R, Zupo S, Noch E . Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002; 99(24):15524-9. PMC: 137750. DOI: 10.1073/pnas.242606799. View

Ali Syeda Z, Langden S, Munkhzul C, Lee M, Song S . Regulatory Mechanism of MicroRNA Expression in Cancer. Int J Mol Sci. 2020; 21(5). PMC: 7084905. DOI: 10.3390/ijms21051723. View

Hanahan D, Weinberg R . The hallmarks of cancer. Cell. 2000; 100(1):57-70. DOI: 10.1016/s0092-8674(00)81683-9. View

Vaupel P, Schmidberger H, Mayer A . The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression. Int J Radiat Biol. 2019; 95(7):912-919. DOI: 10.1080/09553002.2019.1589653. View

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

Lu J . The Warburg metabolism fuels tumor metastasis. Cancer Metastasis Rev. 2019; 38(1-2):157-164. DOI: 10.1007/s10555-019-09794-5. View

Zheng J . Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). Oncol Lett. 2012; 4(6):1151-1157. PMC: 3506713. DOI: 10.3892/ol.2012.928. View

10.

Palm W, Thompson C . Nutrient acquisition strategies of mammalian cells. Nature. 2017; 546(7657):234-242. PMC: 5541675. DOI: 10.1038/nature22379. View

11.

Trefely S, Doan M, Snyder N . Crosstalk between cellular metabolism and histone acetylation. Methods Enzymol. 2019; 626:1-21. DOI: 10.1016/bs.mie.2019.07.013. View

12.

Narita T, Weinert B, Choudhary C . Functions and mechanisms of non-histone protein acetylation. Nat Rev Mol Cell Biol. 2018; 20(3):156-174. DOI: 10.1038/s41580-018-0081-3. View

13.

Feron O . The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression. Ann Transl Med. 2020; 7(Suppl 8):S277. PMC: 6976516. DOI: 10.21037/atm.2019.11.140. View

14.

Faubert B, Solmonson A, DeBerardinis R . Metabolic reprogramming and cancer progression. Science. 2020; 368(6487). PMC: 7227780. DOI: 10.1126/science.aaw5473. View

15.

Janiszewska M, Primi M, Izard T . Cell adhesion in cancer: Beyond the migration of single cells. J Biol Chem. 2020; 295(8):2495-2505. PMC: 7039572. DOI: 10.1074/jbc.REV119.007759. View

16.

Ebnet K . Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development. Physiol Rev. 2017; 97(4):1529-1554. DOI: 10.1152/physrev.00004.2017. View

17.

Hamidi H, Ivaska J . Every step of the way: integrins in cancer progression and metastasis. Nat Rev Cancer. 2018; 18(9):533-548. PMC: 6629548. DOI: 10.1038/s41568-018-0038-z. View

18.

Taefehshokr S, Taefehshokr N, Hemmat N, Hajazimian S, Isazadeh A, Dadebighlu P . The pivotal role of MicroRNAs in glucose metabolism in cancer. Pathol Res Pract. 2020; 217:153314. DOI: 10.1016/j.prp.2020.153314. View

19.

Oh S, Kim H, Nam K, Shin I . Glut1 promotes cell proliferation, migration and invasion by regulating epidermal growth factor receptor and integrin signaling in triple-negative breast cancer cells. BMB Rep. 2016; 50(3):132-137. PMC: 5422025. DOI: 10.5483/bmbrep.2017.50.3.189. View

20.

Zhang B, Xie Z, Li B . The clinicopathologic impacts and prognostic significance of GLUT1 expression in patients with lung cancer: A meta-analysis. Gene. 2018; 689:76-83. DOI: 10.1016/j.gene.2018.12.006. View