Paola Defilippi
Overview
Explore the profile of Paola Defilippi including associated specialties, affiliations and a list of published articles.
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Articles
77
Citations
2474
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Recent Articles
1.
Ponzone L, Audrito V, Landi C, Moiso E, Levra Levron C, Ferrua S, et al.
Mol Cancer
. 2024 May;
23(1):105.
PMID: 38755661
Background: The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF-mutated cutaneous metastatic melanoma (MM) is the development of therapeutic resistance. We aimed to assess in...
2.
Centonze G, Natalini D, Grasso S, Morellato A, Salemme V, Piccolantonio A, et al.
Cell Death Dis
. 2023 Dec;
14(12):849.
PMID: 38123597
p140Cap is an adaptor protein involved in assembling multi-protein complexes regulating several cellular processes. p140Cap acts as a tumor suppressor in breast cancer (BC) and neuroblastoma patients, where its expression...
3.
Salemme V, Centonze G, Avalle L, Natalini D, Piccolantonio A, Arina P, et al.
Front Oncol
. 2023 Jun;
13:1170264.
PMID: 37265795
Breast cancer is a highly heterogeneous disease, at both inter- and intra-tumor levels, and this heterogeneity is a crucial determinant of malignant progression and response to treatments. In addition to...
4.
Salemme V, Vedelago M, Sarcinella A, Moietta F, Piccolantonio A, Moiso E, et al.
Nat Commun
. 2023 May;
14(1):2350.
PMID: 37169737
The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events...
5.
Angelini C, Morellato A, Alfieri A, Pavinato L, Cravero T, Bianciotto O, et al.
J Neurosci
. 2022 Aug;
42(38):7183-7200.
PMID: 35953295
The NMDARs are key players in both physiological and pathologic synaptic plasticity because of their involvement in many aspects of neuronal transmission as well as learning and memory. The contribution...
6.
Centonze G, Natalini D, Piccolantonio A, Salemme V, Morellato A, Arina P, et al.
Front Oncol
. 2022 Jun;
12:906670.
PMID: 35719918
Cholesterol is an essential lipid primarily synthesized in the liver through the mevalonate pathway. Besides being a precursor of steroid hormones, bile acid, and vitamin D, it is an essential...
7.
Quirico L, Orso F, Cucinelli S, Paradzik M, Natalini D, Centonze G, et al.
Cell Mol Life Sci
. 2022 Mar;
79(4):216.
PMID: 35348905
MicroRNAs (miRNAs) are small, non-coding RNAs about 22 nucleotides in length that regulate the expression of target genes post-transcriptionally, and are highly involved in cancer progression. They are able to...
8.
Camera M, Russo I, Zamboni V, Ammoni A, Rando S, Morellato A, et al.
Front Neurosci
. 2022 Mar;
16:744693.
PMID: 35237119
p140Cap, encoded by the gene (, is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms. knock-out (KO) female mice show severe hypofertility,...
9.
Avalle L, Raggi L, Monteleone E, Savino A, Viavattene D, Statello L, et al.
Oncogene
. 2022 Jan;
41(10):1456-1467.
PMID: 35042959
In the tumor microenvironment, Cancer Associated Fibroblasts (CAFs) become activated by cancer cells and increase their secretory activity to produce soluble factors that contribute to tumor cells proliferation, invasion and...
10.
Costamagna A, Natalini D, Camacho Leal M, Simoni M, Gozzelino L, Cappello P, et al.
Gastroenterology
. 2021 Dec;
162(4):1242-1255.e11.
PMID: 34922945
Background & Aims: Acinar to ductal metaplasia is the prerequisite for the initiation of Kras-driven pancreatic ductal adenocarcinoma (PDAC), and candidate genes regulating this process are emerging from genome-wide association...