Prevalence of Mental Health Conditions Among People Living with HIV During the COVID-19 Pandemic: A Rapid Systematic Review and Meta-analysis

Overview

Journal HIV Med

Publisher Wiley

Specialty Infectious Diseases

Date 2022 Mar 19

PMID 35304829

Authors

Kai Wei Lee

Chin Siang Ang

Sin How Lim

Ching Sin Siau

Lai Teik Derek Ong

Siew Mooi Ching

Pei Boon Ooi

Affiliations

Soon will be listed here.

Abstract

Background: The COVID-19 pandemic has generated many mental health problems worldwide. People living with HIV (henceforth known as PLHIV) bear a higher mental health burden in comparison with the general population. Therefore, their risk of mental health problems may be elevated during the pandemic.

Methods: We conducted a systematic review and meta-analysis to assess the prevalence of depression, anxiety, psychological stress, insomnia and loneliness among PLHIV during the COVID-19 pandemic. Observational studies in four databases published from 1 January 2020 to 30 April 2021 investigating the prevalence of mental health conditions during the COVID-19 pandemic were searched, and 197 articles were retrieved. After the processes of duplication removal, eligibility screening and full-text assessment, 10 articles were included in the systematic review and six articles for meta-analyses. A random-effects model was applied to derive the pooled prevalence of mental health conditions. The risk of bias was assessed using the STROBE checklist.

Results: Overall, the pooled prevalence rates of (moderate-to-severe) depression and anxiety among PLHIV were 16.9% [95% confidence interval (CI): 3.8%-30.0%] and 23.0% (95% CI: 12.0%-34.0%), respectively.

Conclusions: More research is needed to investigate the mechanism by which the pandemic affects the mental health of PLHIV. Support and programmes are needed to ameliorate the mental health problems in this marginalized population.

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References

Ballivian J, Alcaide M, Cecchini D, Jones D, Abbamonte J, Cassetti I . Impact of COVID-19-Related Stress and Lockdown on Mental Health Among People Living With HIV in Argentina. J Acquir Immune Defic Syndr. 2020; 85(4):475-482. DOI: 10.1097/QAI.0000000000002493. View

Miller A, Lee B, Henderson C . Death anxiety in persons with HIV/AIDS: a systematic review and meta-analysis. Death Stud. 2014; 36(7):640-63. DOI: 10.1080/07481187.2011.604467. View

Song J, Lee J, Seo Y, Kim I, Noh J, Baek J . Depression Among HIV-infected Patients in Korea: Assessment of Clinical Significance and Risk Factors. Infect Chemother. 2013; 45(2):211-6. PMC: 3780946. DOI: 10.3947/ic.2013.45.2.211. View

Anderson R, Heesterbeek H, Klinkenberg D, Hollingsworth T . How will country-based mitigation measures influence the course of the COVID-19 epidemic?. Lancet. 2020; 395(10228):931-934. PMC: 7158572. DOI: 10.1016/S0140-6736(20)30567-5. View

Remien R, Stirratt M, Nguyen N, Robbins R, Pala A, Mellins C . Mental health and HIV/AIDS: the need for an integrated response. AIDS. 2019; 33(9):1411-1420. PMC: 6635049. DOI: 10.1097/QAD.0000000000002227. View

Wagner G, Ghosh-Dastidar B, Holloway I, Kityo C, Mugyenyi P . Depression in the pathway of HIV antiretroviral effects on sexual risk behavior among patients in Uganda. AIDS Behav. 2011; 16(7):1862-9. DOI: 10.1007/s10461-011-0051-7. View

Rooks-Peck C, Adegbite A, Wichser M, Ramshaw R, Mullins M, Higa D . Mental health and retention in HIV care: A systematic review and meta-analysis. Health Psychol. 2018; 37(6):574-585. PMC: 6103311. DOI: 10.1037/hea0000606. View

Wang T, Fu H, Kaminga A, Li Z, Guo G, Chen L . Prevalence of depression or depressive symptoms among people living with HIV/AIDS in China: a systematic review and meta-analysis. BMC Psychiatry. 2018; 18(1):160. PMC: 5984474. DOI: 10.1186/s12888-018-1741-8. View

Brooks S, Webster R, Smith L, Woodland L, Wessely S, Greenberg N . The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020; 395(10227):912-920. PMC: 7158942. DOI: 10.1016/S0140-6736(20)30460-8. View

10.

Marbaniang I, Sangle S, Nimkar S, Zarekar K, Salvi S, Chavan A . The burden of anxiety among people living with HIV during the COVID-19 pandemic in Pune, India. BMC Public Health. 2020; 20(1):1598. PMC: 7582417. DOI: 10.1186/s12889-020-09656-8. View

11.

Galea S, Merchant R, Lurie N . The Mental Health Consequences of COVID-19 and Physical Distancing: The Need for Prevention and Early Intervention. JAMA Intern Med. 2020; 180(6):817-818. DOI: 10.1001/jamainternmed.2020.1562. View

12.

Guimaraes M, McKinnon K, Cournos F, Machado C, Melo A, Campos L . Correlates of HIV infection among patients with mental illness in Brazil. AIDS Care. 2013; 26(4):505-13. PMC: 4554532. DOI: 10.1080/09540121.2013.832722. View

13.

Krumme A, Kaigamba F, Binagwaho A, Murray M, Rich M, Franke M . Depression, adherence and attrition from care in HIV-infected adults receiving antiretroviral therapy. J Epidemiol Community Health. 2014; 69(3):284-9. DOI: 10.1136/jech-2014-204494. View

14.

Fodjo J, Villela E, van Hees S, Vanholder P, Reyntiens P, Colebunders R . Follow-Up Survey of the Impact of COVID-19 on People Living with HIV during the Second Semester of the Pandemic. Int J Environ Res Public Health. 2021; 18(9). PMC: 8123847. DOI: 10.3390/ijerph18094635. View

15.

Pizzirusso M, Carrion-Park C, Clark U, Gonzalez J, Byrd D, Morgello S . Physical and Mental Health Screening in a New York City HIV Cohort During the COVID-19 Pandemic: A Preliminary Report. J Acquir Immune Defic Syndr. 2020; 86(3):e54-e60. PMC: 7878300. DOI: 10.1097/QAI.0000000000002564. View

16.

Ciesla J, Roberts J . Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry. 2001; 158(5):725-30. DOI: 10.1176/appi.ajp.158.5.725. View

17.

Reynolds B, Basso M, Miller A, Whiteside D, Combs D . Executive function, impulsivity, and risky behaviors in young adults. Neuropsychology. 2018; 33(2):212-221. DOI: 10.1037/neu0000510. View

18.

Peteet J . COVID-19 Anxiety. J Relig Health. 2020; 59(5):2203-2204. PMC: 7227179. DOI: 10.1007/s10943-020-01041-4. View

19.

Chenneville T, Gabbidon K, Hanson P, Holyfield C . The Impact of COVID-19 on HIV Treatment and Research: A Call to Action. Int J Environ Res Public Health. 2020; 17(12). PMC: 7345635. DOI: 10.3390/ijerph17124548. View

20.

Algarin A, Zhou Z, Cook C, Cook R, Ibanez G . Age, Sex, Race, Ethnicity, Sexual Orientation: Intersectionality of Marginalized-Group Identities and Enacted HIV-Related Stigma Among People Living with HIV in Florida. AIDS Behav. 2019; 23(11):2992-3001. PMC: 6803104. DOI: 10.1007/s10461-019-02629-y. View